CAS: 17702-83-9; 2-(8-Bromooctyl)Isoindoline-1,3-Dione

该化合物是一种有机化合物,其特点是其二氟硫化物结构,这是一种源自二氟硫酸的环状浸渍物,该化合物具有溴化八丁基链,特别是八溴基锡化合物组,它助长其疏水特性并影响其反应性.该物质在室内温度下一般是白色到非白色的固体,在二氯甲烷和丙酮等有机溶剂中溶解,但水溶解性有限.溴原子的存在会增加其作为各种化学反应反应中反应中间体的潜力,包括核细胞替代物.N-(8-Bromooctyl)二氟化物经常用于有机合成,特别是在准备表面活性剂,聚合物和其他功能材料时.此外,它的独特结构允许在医药化学和材料科学中应用.在处理该化合物时,应注意安全防范措施,因为如果吸入或吸入,可能会对健康造成危害.

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CAS号4549-32-0 1,8-二溴辛烷 | CAS号1074-82-4 邻苯二甲酰亚胺钾盐 | CAS号105264-63-9 N-(8-羟辛基)邻苯二甲酰亚胺 | CAS号1875-48-5 N-氨基邻苯二甲酰亚胺 | CAS号6279-57-8 N,N-dipropyl°Ct...

合成工艺路线路线简述

    📜8-溴-1-辛醇置于四溴化碳,三苯基膦体系中,用 N,N-二甲基甲酰胺,乙腈 用作溶剂,化学反应 2.5H,反应生成N-(8-溴辛基)邻苯二甲酰亚胺
    参考文献: Pyridinyl Derivatives As Inhibitors Of Enzyme Nicotinamide Phosphoribosyltransferase[fr] Dérivés De Pyridinyle Utilisés En Tant Qu'Inhibiteurs De L'Enzyme Nicotinamide Phosphoribosyltransférase
    标题: Pyridinyl Derivatives As Inhibitors Of Enzyme Nicotinamide Phosphoribosyltransferase[fr] Dérivés De Pyridinyle Utilisés En Tant Qu'Inhibiteurs De L'Enzyme Nicotinamide Phosphoribosyltransférase
    摘要:本申请公开了一种化合物,其化学式为(i),其中q是可选择取代的吡啶基;P为0-6;Y是式(i),(II)和(III),其中x为=o,=s和=n-Cn,R为1-12,R为-Z-A,Z为单键,-S(=o)2-,>P=o,>C=o,-C(=o)Nh-和-C(=s)Nh-;A为氢,C1-12-烷基,C3-12-环烷基,-[ch2Ch2O]1-10-(C1-6-烷基),C1-12-烯基,芳基,杂环烷基和杂芳基;B为单键,-Nrn-,-S(=o)2-和-O-;其中rn从氢,C1-12-烷基,C3-12-环烷基,-[ch2Ch2O]1-10-(C1-6-烷基),C1-12-烯基,芳基,杂环烷基和杂芳基中选择;S为0-6;Cy为芳基,环烷基,杂环烷基和杂芳基.这些化合物可用作治疗由烟酰胺磷酸核糖转移酶(namprt)水平升高引起的疾病或症状的药物.

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    专利信息


    专利号:US-4261974-A
    优先权日:1979-11-13
    标题:Valproic acid immunogen conjugates and antibodies thereto
    发明人：BUCKLER ROBERT T; BURD JOHN F; WONG RAPHAEL C
    权利人:MILES LAB
    摘要:Reagents for use in binding assays, particularly immunoassays, to determine valproic acid in liquid media such as serum. Such reagents include antibody to valproic acid and β-galactosyl-umbelliferone-valproic acid conjugates. Also provided are compounds used to prepare such reagents, including valproic acid immunogen conjugates and intermediates in the synthesis of such immunogen conjugates and β-galactosyl-umbelliferone-labeled conjugates.

    专利号:US-4292425-A
    优先权日:1979-11-13
    标题 :βGalactosyl-umbelliferone valproic acid conjugates
    发明人：BUCKLER ROBERT T; BURD JOHN F; WONG RAPHAEL C
    权利人:MILES LAB
    摘要:Reagents for use in binding assays, particularly immunoassays, to determine valproic acid in liquid media such as serum. Such reagents include antibody to valproic acid and β-galactosyl-umbelliferone-valproic acid conjugates. Also provided are compounds used to prepare such reagents, including valproic acid immunogen conjugates and intermediates in the synthesis of such immunogen conjugates and β-galactosyl-umbelliferone-labeled conjugates.

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    主要参考文献

    参考标题:Synthesis Of Bivalent Organophosphorus Compounds As Acetylcholinesterase Inhibitors
    作者:Guoquan Yang,Qianfei Zhao,Yonghong Li,Huizhu Yuan,Xiangdong Mei,Jun Ning |发布日期:2008.10
    摘要:Glu199, Asp-276 And The Hydrophobic Residues Lining The Entrance Gorge Of Ache Through Binding To Both Catalytic And Peripheral Sites Of The Enzyme, A New Series Of Dual Binding Site Ache Inhibitors Have Been Designed And Synthesized.1° The Cluster Effect, Combined With Information About The Structure Of Acetylcholinesterase, Led Us To Design And Synthesize Some Bivalent Organphosphorus Compounds As

    合成参考文献


    参考文献:10.1021/jo025978o
    摘要:Dumas C, Schibli R, Schubiger PA. Versatile routes to C-2- and C-6-functionalized glucose derivatives of iminodiacetic acid. J Org Chem. 2003 Jan 24;68(2):512–8. doi: 10.1021/jo025978o.
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