CAS: 17680-84-1; 5-Hydroxy-2-(4-Hydroxyphenyl)-6-Methoxy-7-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One

上下游产品

CAS号2280-44-6 D-glucopyranose | CAS号1447-88-7 高车前素

Hispidulin 7-O-Glucuronide Methyl Ester置于sodium Tetrahydroborate体系中,用 甲醇 用作溶剂,化学反应 1.0H,以79%的收率获得高车前苷
参考文献:半苷中一系列天然黄酮类和黄酮苷的半合成
标题:半苷中一系列天然黄酮类和黄酮苷的半合成
摘要:天然类黄酮和类黄酮糖苷存在于许多植物中,并已证明具有多种临床上相关的特性,从植物来源中分离出大量具有惊人结构相似性的化合物需要繁琐的分离技术.这些过程限制了它们在结构-活性关系(sar)研究中结构多样性的可用性,并限制了大量例如用于体内机理评估的过程活动.在这项工作中,我们从黄苷开发了一种半合成策略,用于合成一系列天然黄酮类和黄酮苷.通过这种策略,有效地和实用地合成了八个具有惊人结构相似性的生物活性类黄酮.获得的足够量的产物将极大地促进sar研究和体内活性的机械评价.
Doi:10.1016/j.Tet.2020.130950

专利信息

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.