CAS: 160347-90-0; (R)-1-(Tert-Butoxycarbonyl)-5-Oxopyrrolidine-2-Carboxylic Acid

该化合物是一种化学化合物,其结构特征包括一个与氨酸D-tyrosine附属的乙型丁氧碳酸(Boc)保护组,该化合物通常用于浸渍合成和有机化学,作为氨酸D-tyrosine的一个保护组,允许在不受到矿物质功能干扰的情况下有选择地作出反应;芳香环上存在氢氧基化合物,有助于其再活性和溶解性;BOC-D-PYR-OH经常被用于合成药物和生物活性化合物,因为它能够促进形成丙酸联结,同时保持氨酸侧链的完整性;在标准实验室条件下,该化合物的稳定性使它成为合成途径中有价值的中间体;与许多化学物质一样,适当的处理和储存对于确保安全并保持其研究和应用目的的完整性至关重要.

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160401-16-1 149-87-1 32159-21-0

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上下游产品

L-glutamic acid 2-hydroxymethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester 4-nitrobenzyl L-1-tert-butoxycarbonylpyroglutamate benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinatetert-butyl (S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-oxopyrrolidin-1-carboxylate (S)-tert-butyl 2-(((tert-butyldimethylsilyl)oxy)methyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate tert-butyl (1S,6R)-3-formyl-6-hydroxycyclohex-3-enylcarbamate ethyl (4R,5S)-5-(tert-butoxycarbonylamino)-4-hydroxycyclohex-1-enecarboxylate

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    专利信息


    专利号:US-8835466-B2
    优先权日:2006-04-20
    标 题 :Synthesis and uses of pyroglutamic acid derivatives
    发明人：à LVAREZ BUILLA GÓMEZ JULIO; NOVELLA ROBISCO JOSÉ LUIS; MATà A MARTà N MA PAZ; SERNA PEREDA SONIA
    权利人:à LVAREZ BUILLA GÓMEZ JULIO; NOVELLA ROBISCO JOSÉ LUIS; MATà A MARTà N MA PAZ; SERNA PEREDA SONIA; PRODIMED SA
    摘要:Novel pyroglutamic acid derivatives (I), wherein R 1 is —OH, —ORa, wherein Ra is alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, aralkyl or heterocyclyl; R 2 , R 3 and R 4 are independently H, a nitrogen protecting group which hydrolyzes under acidic conditions or phtalamide; X is a pharmaceutically acceptable anion; and Y is a N-containing group; either in the form of their isolated optically active stereoisomers or in the form of mixtures thereof, are useful compounds for enhancing an immuneresponse in a subject and/or for treating tumors, bacterial, fungal or viral infections, or autoimmune diseases.

    专利号:US-2009163555-A1
    优先权日:2006-04-20
    标 题:Synthesis and uses of pyroglutamic acid derivatives

    专利号:EP-2021334-B1
    优先权日:2006-04-20
    标 题:Synthesis and uses of pyroglutamic acid derivatives

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    合成方法参考DOI号:10.1039/p19960000507
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