CAS: 126717-59-7; 3-Bromo-6-Methoxy-2-Picoline

相似化合物

610278-93-8 819069-57-3 1186637-43-3

上下游产品

CAS号63071-03-4 2-甲氧基-6-甲基吡啶 | CAS号54923-31-8 2-羟基-5-溴-6-甲基吡啶... | CAS号74-88-4 碘甲烷 | CAS号124-41-4 甲醇钠 | CAS号39919-65-8 2,5-二溴-6-甲基吡啶 | CAS号100848-70-2 2-甲氧基-4-甲基吡啶 | CAS号3279-76-3 2-羟基-6-甲基吡啶 | CAS号1824-81-3 2-氨基-6-甲基吡啶 | CAS号5315-25-3 2-溴-6-甲基吡啶 | CAS号459856-12-3 (6-甲氧基-2-甲基吡啶-3-基)硼酸 | CAS号156094-77-8 6-甲氧基-2-甲基 烟醛 | CAS号1080028-73-4 6-甲氧基-2-甲基吡啶-3-... | CAS号105277-11-0 6-甲氧基-2-甲基吡啶-3-甲腈 | CAS号132606-40-7 2-甲基-3-溴-6-氯吡啶 | CAS号91618-17-6 6-methoxy-2-met... | CAS号623942-84-7 3-溴-2-羟甲基-6-甲氧基吡啶

2-甲氧基-4-甲基吡啶置于disodium Hydrogenphosphate,溴体系中,用 水 用作溶剂,化学反应 4.25H,以15.4 G的收率获得2-甲氧基-5-溴-6-甲基吡啶
参考文献:Synthesis And Structure−activity Relationships Of 8-(Pyrid-3-yl)Pyrazolo[1,5-A]-1,3,5-Triazines: Potent,Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (Crf1) Antagonists
标题:Synthesis And Structure−activity Relationships Of 8-(Pyrid-3-yl)Pyrazolo[1,5-A]-1,3,5-Triazines: Potent,Orally Bioavailable Corticotropin Releasing Factor Receptor-1 (Crf1) Antagonists
摘要:This Report Describes The Syntheses And Structure-Activity Relationships Of 8-(Substituted Pyridyl)Pyrazolo[1,5-A]-1,3,5-Triazine Corticotropin Releasing Factor Receptor-1 (Crf1) Receptor Antagonists. These Crf1 Receptor Antagonists May Be Potential Anxiolytic Or Antidepressant Drugs. This Research Resulted In The Discovery Of Compound 13-15,Which Is A Potent,Selective Crf1 Antagonist (Hcrf(1) Ic50 = 6.1 +/-0.6 Nm) With Weak Affinity For The Crf-Binding Protein And Biogenic Amine Receptors. This Compound Also Has A Good Pharmacokinetic Profile In Dogs. Analogue 13-15 Is Orally Effective In Two Rat Models Of Anxiety: The Defensive Withdrawal (Situational Anxiety) Model And The Elevated Plus Maze Test. Analogue 13-15 Has Been Advanced To Clinical Trials.
Doi:10.1021/jm900025H

专利信息

专利号:EP-3434669-B1
优先权日:2011-03-04
标 题 :Intermediate compounds utilizable in synthesis of (-) huperzine and process for obtain one of these intermediate compounds

专利号:EP-3434669-A1
优先权日:2011-03-04
标 题 :Intermediate compounds utilizable in synthesis of (-) huperzine and process for obtain one of these intermediate compounds