CAS: 125966-89-4; 4,6-Dimethoxypyrimidine-2-Carbaldehyde

该化合物是一种多用途的抗虫菊酯衍生物,其特征是4和6个位置的碱性功能组和甲氧替代成分.该化合物是有机合成中的宝贵中间体,特别是在制药,农用化学品和三环化合物的制作中.其电子富集的丙酰胺核心和反应性甲酰胺组促进了选择性的修改,从而有利于构建复杂的分子框架.甲氧基化合物组增强了稳定性和影响再活动,提供了受控的功能化.由于高纯度和持续性能,该化合物适合需要精确合成转化的研究和工业应用.建议适当的处理和储存以保持其完整性.

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CAS号125966-88-3 4,6-二甲氧基-2-嘧啶甲醇 | CAS号13566-48-8 4,6-二甲氧基-2-甲基嘧啶

合成工艺路线路线简述

    📜2-Acetoxymethyl-4,6-Dimethoxypyrimidine置于potassium Carbonate,Pyridinium Chlorochromate体系中,用 甲醇,二氯甲烷 用作溶剂,化学反应 13.25H,反应生成4,6-二甲氧基-2-嘧啶羧醛
    参考文献:某些取代的嘧啶类化合物作为潜在的血吸虫剂的合成
    标题:某些取代的嘧啶类化合物作为潜在的血吸虫剂的合成
    摘要:据报道,一种方便的路线用于合成七个新的嘧啶衍生物,即:2-溴甲基--4,6-二甲氧基嘧啶(3),2-二溴甲基-4,6-二甲氧基嘧啶(4),2-乙酰氧基甲基-4,6-二甲基-氧嘧啶(5),2-羟甲基-4,6-二甲氧基嘧啶(6),4,6-二甲氧基嘧啶-2-羧醛(7),2-乙酰氧基甲基-6-甲氧基-3,4-二氢嘧啶-4-一(8)和2-羟甲基-3,4-二氢-6-甲氧基-嘧啶-4-一(9).
    Doi:10.1002/jhet.5570260406

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    专利信息


    专利号:US-2012178931-A1
    优先权日:2009-08-31
    标题 :Process for preparation of pyrimidinylacetonitrile derivatives and intermediates for synthesis thereof

    专利号:RU-2117666-C1
    优先权日:1991-03-07
    标 题 :Pyridinesulfoneamide and its salts, hydrates and complexes with -alcohols useful in agriculture, herbicide compositions, method of struggle against weeds, method of struggle against foxtail (alopecurus), an intermediate compound for its synthesis

    专利号:EP-2474536-B1
    优先权日:2009-08-31
    标 题 :Process for preparation of pyrimidinylacetonitrile derivatives and intermediates for synthesis thereof
    发明人：KAWAZOE KENTARO
    权利人:IHARA CHEMICAL IND CO

    专利号:EP-2474536-A1
    优先权日:2009-08-31
    标题 :Process for preparation of pyrimidinylacetonitrile derivatives and intermediates for synthesis thereof

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    主要参考文献

    参考标题:Process For Preparation Of Pyrimidinylacetonitrile Derivatives And Intermediates For Synthesis Thereof
    摘要:Provided Is A Process By Which Pyrimidinylacetonitrile Derivatives Can Be Prepared Easily And Efficiently From Industrially Available Raw Materials. Also Provided Are Intermediates For The Synthesis Of The Derivatives. A Process For The Preparation Of Pyrimidinylacetonitrile Derivatives Represented By General Formula (3) [wherein X Is A Halogen Atom, And R Is An Alkoxymethyl Group], Characterized By Reacting A 2,4-Dihalogeno-6-Nitrobenzene Derivative Represented By General Formula (1) [wherein X And R Are Each As Defined Above] With 4,6-Dimethoxy-2-Cyanomethylpyrimidine Represented By General Formula (2) [wherein Me Represents A Methyl Group] In The Presence Of A Base; And Intermediates For The Synthesis Of The Pyrimidinylacetonitrile Derivatives.
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