CAS: 1125-80-0; 3-Methylisoquinoline

该化合物是一种含有分子式C10H9N的热循环芳香化合物. 它在有机合成中,特别是在生产药品,农用化学品和特殊化学品方面,是一个有价值的中间体. 处于3级的甲基组增强了其反应性,使复杂的分子结构能够有选择地发挥功能. 该复合体在标准条件下表现出稳定性,并表明与一系列试剂相容,使之适合多种合成用途. 它的硬性等离子骨干有助于其在医药化学中的用途,因为它在生物活性分子中被用作一个手持器. 高纯度可以满足严格的研究和工业要求.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

3-methyl-3,4-dihydro-isoquinoline 1-chloro-3-methyl-isoquinoline [2-(acetylamino-methyl)-phenyl]-acetic acid acetone enolate ion 3-methyl-2-(3-trimethylammonio-propyl)-isoquinolinium; dibromide 2-propyl-benzylamine trans-3-styrylisoquinoline 2-benzoyl-3-methyl-1,2-dihydroisoquinoline-1-carbonitrile

合成工艺路线路线简述

  • 合成目标产物 3-Methylisoquinoline 主要起始原料 Methylglyoxal 1,1-Dimethyl Acetal And Benzylamine
  • (文献来源)合成步骤主要原料 Methylglyoxal 1,1-Dimethyl Acetal 和 Benzylamine
📜2,2-Diethoxyethanal N-Benzylimine置于氯磺酸,氯化铵体系中,用 乙醚 用作溶剂,化学反应 3.17H,反应生成3-甲基异喹啉
参考文献:Kido,Kazuko; Watanabe,Yasuo,Chemical And Pharmaceutical Bulletin,1987,Vol. 35,# 12,P. 4964-4966
标题:Kido,Kazuko; Watanabe,Yasuo,Chemical And Pharmaceutical Bulletin,1987,Vol. 35,# 12,P. 4964-4966

海关参考信息

专利信息


专利号:US-9755163-B2
优先权日:2010-04-30
标 题:Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof
发明人:LI JIAN; TURNER ERIC
权利人:ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIV; ARIZONA BOARD OF REGENTS ACTING FOR OR ON BEHALF OF ARIZONA STATE UNIV
摘要:Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof.

专利号:US-9324957-B2
优先权日:2010-04-30
标 题:Synthesis of four coordinated gold complexes and their applications in light emitting devices thereof
发明人:LI JIAN; TUMER ERIC
权利人:LI JIAN; TUMER ERIC; UNIV ARIZONA STATE
摘要:Synthesis of four coordinated gold complexes and their applications in light emitting devices thereof.

专利号:WO-2014004985-A1
优先权日:2012-06-29
标题 :1,4-azaborine compounds and methods of synthesis
发明人:LIU SHIH-YUAN; XU SENMIAO; KWONG RAYMOND C
权利人:STATE OF OREGON ACTING BY & THROUGH THE ST BOARD OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF; UNIV DISPLAY CORP
摘要:A compound comprising a structure of formula A

专利号:US-3954771-A
优先权日:1972-06-16
标题 :Process for the preparation of 2H-3-isoquinolones
发明人:GEERTS JEAN-PIERRE JULES; LINZ RAYMOND ARMAND
权利人:UCB SA
摘要:A process for the preparation of 2H-3-isoquinolones having the formula ##SPC1## n Wherein R 1 and R 2 are each hydrogen, halogen, lower alkyl, lower alkoxy, aryl, haloaryl, alkylaryl or alkoxyaryl; R 3 and R 4 are each hydrogen, lower alkyl, lower alkoxyalkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, aralkyl, or halo-aralkyl, which comprises cyclizing an N-formyl-2-phenyl-acetamide of the formula ##SPC2## n Wherein R 1 , R 2 , R 3 and R 4 have the same meaning as above, with a cyclodehydration agent. Said 2H-3-isoquinolones are useful as starting materials e.g. in the synthesis of 1,4-dihydro-1,4-etheno-isoquinolin-3(2H)-ones which are valuable chemotherapeutic agents in the treatment of disorders of the central nervous system, such as troubles of wakefulness, disorders of equilibrium and vertigo.

专利号:US-9698359-B2
优先权日:2011-05-26
标 题 :Synthesis of platinum and palladium complexes as narrow-band phosphorescent emitters for full color displays
发明人:LI JIAN; TURNER ERIC
权利人:ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIV
摘要:Platinum and palladium complexes are disclosed that can be useful as narrow band phosphorescent emitters. Also disclosed are methods for preparing and using the platinum and palladium complexes.

专利号:US-2007275962-A1
优先权日:2003-09-10
标 题:Heterobicyclic Compounds as Pharmaceutically Active Agents
发明人:KOUL ANIL; KLEBL BERT; MULLER GERHARD; MISSIO ANDREA; SCHWAB WILFRIED; HAFENBRADL DORIS; NEUMANN LARS; SOMMER MARC-NICOLA; MULLER STEFAN; HOPPE EDMUND; FREISLEBEN ACHIM; BACKES ALEXANDER; HARTUNG CHRISTIAN; FELBER BEATRICE; ZECH BIRGIT; ENGKVIST OLA; KERI GYORGY; ORFI LASZLO; BANHEGYI PETER; GREFF ZOLTAN; HORVATH ZOLTAN; VARGA ZOLTAN; MARKO PETER; PATO JANOS; SZABADKAI ISTVAN; SZEKELYHID ZSOLT; WACZEK FRIGYES
权利人:GPC BIOTECH AG
摘要:Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 289.
摘要:Shaabani, A.; Sarvary, A.; Shaabani, S., Science of Synthesis: Multicomponent Reactions, (2013) 2, 103.
摘要:Chen, Z.-P.; Zhou, Y.-G., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 1, 165.
摘要:Bellanger, C.; Chelli, S.; Lakhdar, S., Science of Synthesis, (2021) , 241.
摘要:Liu, Z.-Q., Science of Synthesis, (2020) , 373.
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