CAS: 111060-54-9; (S)-2-(Dibenzylamino)-3-Methyl-1-Butanol

上下游产品

CAS号111060-51-6 (S)-benzyl 2-(d... | CAS号2026-48-4 L-缬氨醇 | CAS号100-39-0 溴化苄 | CAS号72-18-4 l-缬氨酸

📜L-缬氨酸置于sodium Hydroxide,Lithium Aluminium Tetrahydride体系中,化学反应生成N,N-二苄基-L-缬氨醇
参考文献:手性氨基硫醇作为催化剂在二乙基锌对醛的对映选择性加成中的应用
标题:手性氨基硫醇作为催化剂在二乙基锌对醛的对映选择性加成中的应用
摘要:从(S)-(-)-缬氨酸开始,以高效的方式制备了一系列新的手性氨基硫醇和相应的硫代乙酸酯配体,并将其用于不对称二乙基锌锌中的醛,对映体选择性高达99%ee,且对映体选择性高.催化负载仅为氨基硫醇11C的0.02 Mol%.
Doi:10.1016/j.Tetasy.2004.08.009

专利信息

专利号:US-6423871-B1
优先权日:1999-02-26
标题 :Efficient synthesis of secondary amines by selective alkylation of primary amines
发明人：JUNG KYUNG WOON
权利人:UNIV SOUTH FLORIDA
摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23° C.; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73% yield.