CAS: 87-24-1; Ethyl 2-Methylbenzoate

该化合物是芳香酯,其特点是其香味,果味味味,在调味和香味应用中有用,其成分是2-甲基苯酸酸和乙醇的酯化,其成分一般是无色的黄色液体,在水中可中溶解,同时在乙醇和乙醚等有机溶剂中更易溶解;乙酰2-甲基苯甲酸酯的沸点相对较低,导致其挥发性;其化学结构特征为一种苯环,代之以甲基组和乙基酯功能组,影响其再活动与互动;在安全方面,最好谨慎处理这一化合物,因为它可能会对皮肤和眼睛产生刺激;此外,重要的是将其储存在远离点火源的冷,通风良好的地区,因为它是易燃的.总的来说,乙基二甲基苯甲酸盐是一种可变的化合物,其用途在各种行业中,特别是在品味生产中.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号615-37-2 2-碘甲苯 | CAS号64-17-5 乙醇 | CAS号201230-82-2 carbon monoxide | CAS号1906-57-6 乙基草酸钾 | CAS号529-20-4 邻甲基苯甲醛 | CAS号95-46-5 2-溴甲苯 | CAS号16419-60-6 2-甲基苯硼酸 | CAS号541-41-3 氯甲酸乙酯 | CAS号118-90-1 邻甲基苯甲酸 | CAS号35276-81-4 3-氧代-3-(邻甲苯基)丙腈 | CAS号527-84-4 邻伞花烃 | CAS号31842-01-0 2-(4-(1-氧代异吲哚啉-... | CAS号19821-21-7 2-(氰甲基)苯甲酸乙酯 | CAS号87-41-2 苯酞 | CAS号7115-91-5 2-溴甲基苯甲酸乙酯 | CAS号2503-66-4 5-邻甲苯-1,3,4-噁二唑-2-硫醇 | CAS号131-58-8 2-甲基二苯甲酮 | CAS号529-19-1 邻甲基苯腈

合成工艺路线路线简述

  • 118-90-1 = 87-24-1
    反应条件:1.1 Reagents: Thionyl Chloride Solvents: Ethanol; 2 H,Reflux
    标题:Synthesis And Antimicrobial Activity Of New Prenylated 2-Pyrone Derivatives
    作者:Obi,Grace; Et Al
    参考文献:Synthetic Communications 日期:2020 卷标:50(5) 页码:726-734]

    = 87-24-1
    反应条件:1.1 Reagents: Triethylamine Catalysts: 1638843-58-9 (Polystyrene Bounded); 3 H,1 Atm,70 °C
    标题:Polymer Supported Pd Catalyzed Carbonylation Of Aryl Bromides For The Synthesis Of Aryl Esters And Amides
    作者:Islam,Sk Manirul; Et Al
    参考文献:Rsc Advances 日期:2014 卷标:4(73) 页码:38986-38999]

    6091-64-1 = 87-24-1
    反应条件:1.1 Reagents: Sec-Butyllithium Solvents: Tetrahydrofuran,Hexane,Cyclohexane; -48 °C1.2 Solvents: Tetrahydrofuran; -48 °C1.3 Reagents: Ammonium Chloride Solvents: Water
    标题:A Flow Microreactor System Enables Organolithium Reactions Without Protecting Alkoxycarbonyl Groups
    作者:Nagaki,Aiichiro; Et Al
    参考文献:Chemistry - A European Journal 日期:2010 卷标:16(36) 页码:11167-11177]

    1906-57-6 = 87-24-1
    反应条件:1.1 Catalysts: 1,3-Bis(Diphenylphosphino)Propane,Palladium Trifluoroacetate Solvents: N-Methyl-2-Pyrrolidone; Rt; 24 H,145 - 155 °C
    标题:Synthesis Of Aromatic Esters Via Pd-Catalyzed Decarboxylative Coupling Of Potassium Oxalate Monoesters With Aryl Bromides And Chlorides
    作者:Shang,Rui; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2009 卷标:131(16) 页码:5738-5739]

    615-37-2 = 87-24-1
    反应条件:1.1 Catalysts: Tetramethylurea,Dichlorobis(Triphenylphosphine)Palladium
    标题:Preparation Of Carboxylic Acid Derivatives
    参考文献:Japan]

    161912-33-0 = 87-24-1
    反应条件:1.1 Reagents: Sodium Acetate Catalysts: Palladium Diacetate,(1R)-1-[(1R)-1-[bis(1,1-Dimethylethyl)Phosphino]Ethyl]-2-(Diethylphosphino)Ferro... Solvents: Ethanol; 20 H,135 °C
    标题:An Efficient Catalyst For Pd-Catalyzed Carbonylation Of Aryl Arenesulfonates
    作者:Cai,Chaoxian; Et Al
    参考文献:Organic Letters 日期:2006 卷标:8(22) 页码:5161-5164]

    118-90-1 = 87-24-1
    反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Trihexyl(Tetradecyl)Phosphonium Bis(Trifluoromethylsulfonyl)Imide; 10 Min,30 °C1.2 12 H,30 °C
    标题:Scope And Mechanistic Insights Into The Use Of Tetradecyl(Trihexyl)Phosphonium Bistriflimide: A Remarkably Selective Ionic Liquid Solvent For Substitution Reactions
    作者:Mcnulty,James; Et Al
    参考文献:Chemistry - A European Journal 日期:2006 卷标:12(36) 页码:9314-9322]

    221635-86-5 = 87-24-1
    反应条件:1.1 Solvents: Acetonitrile; 1 H,Rt; 72 H,Rt
    标题:Photochemical Reactions Of 1,3,3-Trimethylbicyclo[2.2.2]Octa-5,7-Dien-2-Ones
    作者:Chang,Shi-Yi; Et Al
    参考文献:European Journal Of Organic Chemistry 日期:2006 卷标:(20) 页码:4648-4657]

    529-20-4 = 87-24-1
    反应条件:1.1 Reagents: Cesium Carbonate,Manganese Oxide (Mno2),1,8-Diazabicyclo[5.4.0]Undec-7-Ene Catalysts: 1-Butyl-3-Methylimidazolium Tetrafluoroborate Solvents: 1-Butyl-3-Methylimidazolium Tetrafluoroborate; Rt; 24 H,Rt
    标题:The Dual Role Of Ionic Liquid Bmimbf4,Precursor Of N-Heterocyclic Carbene And Solvent,In The Oxidative Esterification Of Aldehydes
    作者:Chiarotto,Isabella; Et Al
    参考文献:Tetrahedron 日期:2013 卷标:69(37) 页码:8088-8095]

    527-85-5 = 87-24-1
    反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: Ferric Chloride Hexahydrate Solvents: Hexane,Water; 14 H,80 °C1.2 Reagents: Sodium Chloride Solvents: Water; Neutralized
    标题:Fe-Catalyzed Esterification Of Amides Via C-N Bond Activation
    作者:Chen,Xiuling; Et Al
    参考文献:Rsc Advances 日期:2018 卷标:8(9) 页码:4571-4576]

    118-90-1 = 87-24-1
    反应条件:1.1 Reagents: Sulfuric Acid Solvents: Ethanol; 12 H,Reflux; Reflux -> Rt1.2 Reagents: Sodium Carbonate Solvents: Water; Neutralized,Rt
    标题:Smi2-Catalyzed Intermolecular Coupling Of Cyclopropyl Ketones And Alkynes: A Link Between Ketone Conformation And Reactivity
    作者:Agasti,Soumitra; Et Al
    参考文献:Journal Of The American Chemical Society 日期:2021 卷标:143(9) 页码:3655-3661]

    118-90-1 = 87-24-1
    反应条件:1.1 Catalysts: Sulfuric Acid; 13 H,110 - 120 °C
    标题:A Simple,Efficient,Green,Cost Effective And Chemoselective Process For The Esterification Of Carboxylic Acids
    作者:Rekha,Vamsi V.; Et Al
    参考文献:Organic Process Research & Development 日期:2009 卷标:13(4) 页码:769-773]

    6091-64-1 = 87-24-1
    反应条件:1.1 Reagents: Zinc,Sodium Iodide Catalysts: Dichloro[1,1′-(1,3-Propanediyl)Bis[1,1-Diphenylphosphine-Kp]]Nickel Solvents: Tetrahydrofuran; 24 H,Rt
    标题:Nickel-Catalyzed Methylation Of Aryl Halides With Deuterated Methyl Iodide
    作者:Hu,Lu; Et Al
    参考文献:Angewandte Chemie 日期:2016 卷标:55(33) 页码:9743-9747]

    6091-64-1 = 87-24-1
    反应条件:1.1 Reagents: Sec-Butyllithium Solvents: Tetrahydrofuran,Hexane,Cyclohexane; Rt -> -48 °C; 0.06 S,-48 °C1.2 Solvents: Tetrahydrofuran; 2.3 S,-48 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; 30 S,Cooled
    标题:Aryllithium Compounds Bearing Alkoxycarbonyl Groups: Generation And Reactions Using A Microflow System
    作者:Nagaki,Aiichiro; Et Al
    参考文献:Angewandte Chemie 日期:2008 卷标:47(41) 页码:7833-7836]

    118-90-1 + 866-23-9 = 87-24-1 [标题:Reaction Conditions
    标题:A High Yield Route To Ethyl Esters Of Carboxylic Acids
    作者:Downie,Ian M.; Et Al
    参考文献:Tetrahedron 日期:1982 卷标:38(10)]

    615-37-2 = 87-24-1
    反应条件:1.1 Reagents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Catalysts: Palladium Diacetate Solvents: Ethanol; 10 Bar,Rt; Rt -> 125 °C; 20 Min,125 °C; 30 Bar,125 °C; 125 °C -> 50 °C; 20 Min,50 °C1.2 Reagents: Sodium Chloride Solvents: Diethyl Ether,Water; 50 °C
    标题:Alkoxycarbonylation Of Aryl Iodides Using Gaseous Carbon Monoxide And Pre-Pressurized Reaction Vessels In Conjunction With Microwave Heating
    作者:Kormos,Chad M.; Et Al
    参考文献:Organic & Biomolecular Chemistry 日期:2007 卷标:5(1) 页码:65-68]

    615-37-2 = 87-24-1
    反应条件:1.1 Catalysts: Dichlorobis(Triphenylphosphine)Palladium Solvents: Tetrahydrofuran
    标题:Transition Metal Complex Catalyzed Carbonylation Of Organic Halides In The Presence Of Molecular Sieves Instead Of Base
    作者:Urata,Hisao; Et Al
    参考文献:Tetrahedron Letters 日期:1991 卷标:32(36) 页码:4733-6]

    28276-79-1 = 87-24-1
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 8 H,55 °C
    标题:Licl-Promoted Pd(Ii)-Catalyzed Ortho Carbonylation Of N,N-Dimethylbenzylamines
    作者:Li,Hu; Et Al
    参考文献:Dalton Transactions 日期:2010 卷标:39(43) 页码:10442-10446]

    118-90-1 = 87-24-1
    反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Trihexyl(Tetradecyl)Phosphonium Bis(Trifluoromethylsulfonyl)Imide; 10 Min,30 °C1.2 12 H,30 °C
    标题:A Mild Esterification Process In Phosphonium Salt Ionic Liquid
    作者:Mcnulty,James; Et Al
    参考文献:Tetrahedron Letters 日期:2005 卷标:46(21) 页码:3641-3644]

    635-26-7 = 87-24-1
    反应条件:1.1 Reagents: Triethylamine,Potassium Iodide,Oxygen Catalysts: Palladium; 12 H,3 Bar,100 °C
    标题:Tunable Pd/c-Catalyzed Oxidative Alkoxycarbonylation/aminocarbonylation Of Aryl Hydrazines With Alcohols/inert Tertiary Amines Through C-N Bond Activation
    作者:Kolekar,Yuvraj A.; Et Al
    参考文献:New Journal Of Chemistry 日期:2022 卷标:46(30) 页码:14421-14426]

    = 87-24-1
    反应条件:1.1 Reagents: Manganese Catalysts: Chlorotrimethylsilane,2,2′-Bipyridine,Cobalt Dibromide Solvents: Dimethylformamide,Pyridine; 20 H,60 °C
    标题:Cobalt-Catalyzed Esterification Of Amides
    作者:Bourne-Branchu,Yann; Et Al
    参考文献:Chemistry - A European Journal 日期:2017 卷标:23(42) 页码:10043-10047]

    615-37-2 + 1906-57-6 = 87-24-1
    反应条件:1.1 Catalysts: Palladium Diacetate Solvents: N-Methyl-2-Pyrrolidone; 24 H,140 °C; 140 °C -> Rt
    标题:Ligand Free Palladium Catalyzed Decarboxylative Cross-Coupling Of Aryl Halides With Oxalate Monoester Salts
    作者:Li,Yan; Et Al
    参考文献:Tetrahedron Letters 日期:2012 卷标:53(43) 页码:5796-5799]

    16419-60-6 + 1609-47-8 = 87-24-1
    反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Triphenylphosphine,Palladium Diacetate Solvents: 1,4-Dioxane; 16 H,110 °C
    标题:Palladium-Catalyzed Carbonylations Of Arylboronic Acids: Synthesis Of Arylcarboxylic Acid Ethyl Esters
    作者:Liang,Apeng; Et Al
    参考文献:Advanced Synthesis & Catalysis 日期:2015 卷标:357(14-15) 页码:3104-3108]

    529-20-4 = 87-24-1
    反应条件:1.1 Reagents: Acetone Catalysts: Palladium Diacetate,X-Phos; 20 Min,Rt1.2 Catalysts: Potassium Carbonate; 20 Min,Rt1.3 Overnight,50 °C
    标题:Pd-Catalyzed Aldehyde To Ester Conversion: A Hydrogen Transfer Approach
    作者:Tschaen,Brittany A.; Et Al
    参考文献:Organic Letters 日期:2013 卷标:15(3) 页码:500-503]

    14683-79-5 = 87-24-1
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: 2-Nitrobenzeneseleninic Acid Solvents: Water; Rt
    标题:O-Nitrobenzeneseleninic Acid
    作者:Renga,James M.
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 卷标:1
4-甲基二苯甲酮置于硫酸,溶剂黄146体系中,用 四氯化碳 作为反应溶剂,化学反应 2.0H,以69%的收率获得产物邻甲基苯甲酸乙酯
参考文献:Birkofer,Leonhard; Wahle,Bernd,Chemische Berichte,1983,Vol. 116,# 10,P. 3309-3315
标题:Birkofer,Leonhard; Wahle,Bernd,Chemische Berichte,1983,Vol. 116,# 10,P. 3309-3315

海关参考信息

专利信息


专利号:US-6048991-A
优先权日:1990-11-16
标题:Preparation of epoxides
发明人:HAERMELING DIETER
权利人:BASF AG
摘要:Alpha-hydroxy-epoxides of alpha-alkoxy-epoxides of the formula IV ##STR1## in which the substituents have the following meanings: R 7 , R 8 , R 9 , R 10 , R 11 are independently hydrogen, C 1 -C 20 -alkyl, C 3 -C 12 -cycloalkyl, C 4 -C 20 -cycloalkylalkyl, C 1 -C 20 -hydroxy-alkyl, a heterocyclic ring, or an aryl or C 7 -C 20 -arylalkyl group optionally substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, halogen, C 1 -C 4 -haloalkyl, C 1 -C 4 -halo-alkoxy, phenyl, phenoxy, halophenyl, halophenoxy, carboxy, C 2 -C 8 -alkoxycarbonyl, or cyano, or R 7 and R 8 or R 7 and R 9 or R 7 and R 10 or R 9 and R 10 or R 10 and R 11 together form a (CH 2 ) n group in which n is an integer from 1 to 10 and which may be optionally substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, and/or halogen, and n R 12 is hydrogen, C 1 -C 8 -alkyl, or benzyl, n provided that R 10 is not hydrogen, methyl, ethyl, propyl, or cyclohexyl when R 7 , R 8 , R 9 , or R 11 is hydrogen, that R 7 is not methyl when R 8 is methyl or phenyl and R 9 , R 10 , or R 11 is hydrogen, that R 7 is not methyl when R 8 , R 9 , R 10 , or R 11 is hydrogen and R 12 is ethyl, that R 7 is not phenyl or hexyl when R 8 , R 9 , R 10 , or R 11 is hydrogen, that R 9 is not methyl when R 7 , R 8 , R 10 , or R 11 is hydrogen, that R 10 and R 11 are not methyl when R 7 , R 8 , or R 9 is hydrogen, and that R 7 and R 10 do not together form an unsubstituted cycloalkyl when R 8 , R 9 , or R 11 is hydrogen. The epoxides of the above formula serve as intermediates for the synthesis of, inter alia, perfumes, plant protectants and polymers.

专利号:US-2004053999-A1
优先权日:1997-09-17
标题 :Novel compounds and methods for synthesis and therapy
发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

专利号:CN-105131041-B
优先权日:2015-09-15
标 题 :A novel triphenyl organic bismuth (V) complex catalyst, its preparation method and its catalytic application in the synthesis of nitrogen-containing compounds

专利号:US-4329349-A
优先权日:1979-07-25
标 题:6-C1-4 Alkyl-7-phenyl or substituted phenyl-1,6-naphthyridine-5(6H)-ones
发明人:DAMON II ROBERT E; NADELSON JEFFREY
权利人:SANDOZ AG
摘要:Compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein n R 1 is C 1-4 alkyl, n R 2 is hydrogen, C 1-4 alkyl, C 1-4 alkoxy, halo, trifluoromethyl, C 1-4 alkylthio or --NR 5 R 6 , wherein each of R 5 and R 6 is independently hydrogen or C 1-3 alkyl, n R 3 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy, halo or trifluoromethyl, and n R 4 is hydrogen, C 1-3 alkyl, C 1-3 alkoxy or halo, n their use as muscle relaxants and as anti-inflammatory agents, pharmaceutical compositions comprising them, processes for their synthesis and compounds of the formulae ##STR2## wherein R 1 , R 2 , R 3 and R 4 are as defined above, useful as intermediates in their synthesis.

专利号:US-2008063720-A1
优先权日:2004-04-29
标 题:Delivery System
发明人:GOUNKO IOURI K; RAKOVICH YURY; VOLKOV YURI; DONGEGAN JOHN; KELLEHER DERMOT; MITCHELL SIOBHAN
权利人:GOUNKO IOURI K; RAKOVICH YURY; VOLKOV YURI; DONGEGAN JOHN; KELLEHER DERMOT; MITCHELL SIOBHAN
摘要:Therapeutic drug delivery and diagnostics systems comprise biologically active compounds associated with particulate carriers of less than 20 nm. These systems can be utilised for targeted modification of growth, development and functions, such as gene expression, protein synthesis, intracellular energy production and transport mechanisms in prokaryotic and eukaryotic organisms. The systems are also applicable for controlled modification of structural and functional properties of extracellular components and tissue constituents. The characteristics of a biological site are evaluated and an entity is provided which is dependent on the site characteristics. The entity comprises nanoparticles of less than 20 nm. A probe comprising nanoparticles of less than 5 nm is also provided.

专利号:WO-9314086-A1
优先权日:1992-01-17
标 题 :Substituted 1-isoquinolone derivatives as angiotensin ii antagonists
发明人:FISHER LAWRENCE E; CAROON JOAN M; STABLER STEPHEN R; CLARK ROBIN D
权利人:SYNTEX INC
摘要:1-Isoquinolone derivatives and related compounds according to formula (I) wherein, Y is selected from the group consisting of H, OH, lower alkoxy, and halo; X is selected from the group consisting of H, lower alkyl acid, lower alkyl ester, and lower alkyl; and R1 is selected from the group consisting of H, alkenyl, lower alkyl, lower cycloalkyl, unsubstituted or substituted 3-spiro-1H-indane of structure (II) wherein R2 is H, OH, lower alkyl, lower alkoxy or halo, and 3-spiro-cycloalkyl of structure (III) wherein n is an integer from zero to six, provided that when R1 is spiro- X is H, or a pharmaceutically acceptable salt thereof, with the proviso that when R1 is spiro-, X is H, and when R1 is H, alkenyl, lower alkyl or lower cycloalkyl substituted at the 3-position of the isoquinolone moiety and X is H or lower alkyl, the (2'-1H--tetrazol-5-yl)biphenyl-4'-ylmethyl group cannot be at the 2(N) position, are useful as angiotensin II receptor antagonists. Also disclosed are methods of synthesis, intermediates, pharmaceutical formulations and methods of treatment.
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合成参考文献


摘要:Li, G.; Szostak, M., Science of Synthesis Knowledge Updates, (2020) 2, 231.
摘要:Stanforth, S. P., Science of Synthesis Knowledge Updates, (2015) 1, 180.
摘要:Stanforth, S. P., Science of Synthesis Knowledge Updates, (2015) 1, 215.
摘要:Sanford, M. S.; Cook, A., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 199.
摘要:Satoh, T.; Miura, M., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 202.
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