CAS: 84472-89-9; Cytidine, 3′-Azido-2′,3′-Dideoxy-

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CAS号87190-76-9 [(2S,3S,5R)-3-a... | CAS号84472-88-8 5'-O-acetyl-3'-... | CAS号84472-85-5 那尿苷 | CAS号84472-87-7 Uridine,3'-azid... | CAS号14270-73-6 5'-O-三苯甲基-2'-脱氧尿苷 | CAS号84472-84-4 Uridine,3'-azid... | CAS号6038-53-5 1-[4-methylsulf... | CAS号5983-03-9 1-[4-methylsulf... | CAS号84472-83-3 1-[4-hydroxy-5-... | CAS号84472-90-2 3’-氨基-2’,3’-二脱氧胞苷

📜Navuridine置于甲醇,Ammonium Sulfate,Formamide,六甲基二硅氮烷体系中,化学反应生成 3'-叠氮-2',3'-双脱氧胞苷
参考文献:一些嘧啶的3'-氨基-2',3'-二脱氧核糖核苷:合成和生物活性.
标题:一些嘧啶的3'-氨基-2',3'-二脱氧核糖核苷:合成和生物活性.
摘要:胸腺嘧啶,尿嘧啶和5-碘尿嘧啶的3'-氨基-2',3'-二脱氧核糖核苷(1-3)是通过相应的2'-脱氧核糖核苷通过threo-3'-Chloro和erythro-3'-合成的叠氮基衍生物.以3'-氨基-2',3'-二脱氧胸苷为氨基戊糖基供体,以胸苷磷酸化酶(ec 2.4.2.4)为酶促合成了5-溴尿嘧啶,5-氯尿嘧啶和5-氟尿嘧啶(4-6)的相应氨基核苷催化剂.通过氨基化3'-氨基-2',3'-二脱氧尿苷的3'-叠氮基前体合成3'-氨基-2',3'-二脱氧胞苷(7).在这组氨基核苷中,3'-氨基-2',3'-二脱氧-5-氟尿苷的生物活性显着(6).它对腺病毒的ed50为10 Microm,对培养的哺乳动物细胞没有明显的细胞毒性.它也对某些革兰氏阳性细菌有活性,但对多种革兰氏阴性细菌没有活性.其他氨基核苷(1-5和7)缺乏或表现出弱的抗病毒和抗菌活性.该组中唯一对培养的哺乳动物细胞有明显毒性
DOI:10.1021/jm00360A019

专利信息

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-2020239500-A1
优先权日:2018-04-04
标 题 :Compositions and Methods for Synthesis of Phosphorylated Molecules

专利号:US-2021332070-A1
优先权日:2018-04-04
标题:Compositions and Methods for Synthesis of Phosphorylated Molecules

专利号:US-11021497-B2
优先权日:2018-04-04
标题 :Compositions and methods for synthesis of phosphorylated molecules

专利号:WO-9210496-A1
优先权日:1990-12-05
标 题:ENANTIOMERICALLY PURE β-L-(-)-1,3-OXATHIOLANE NUCLEOSIDES
发明人：CHU CHUNG K; BEACH J WARREN; JEONG LAK-SHIN
权利人:UNIV GEORGIA RES FOUND
摘要:An asymmetric process for the preparation of enantiomerically pure β-L-(-)-1,3-oxathiolane-nucleosides that includes the initial preparation of the key chiral intermediates (2R,5R) and (2R,5S)-5-(O-protected)-2-(protected-oxymethyl)-1,3-oxathiolane from 1,6-thioanhydro-L-gulose. The 2R,5(R,S)-5-(O-protected)-2-(protected-oxymethyl)-1,3-oxathiolane is condensed with a desired heterocyclic base, typically a purine or pyrimidine base, to provide the product nucleoside. The synthesis can be used to prepare the pharmaceutically important compound, β-L-(-)-1-[(2β,4β)-2-(hydroxymethyl)-4-(1,3-thioxolane)]cytosine (β-L-(-)BCH-189).

专利号:US-5248776-A
优先权日:1990-12-05
标题 :Process for enantiomerically pure β-L-1,3-oxathiolane nucleosides
发明人：CHU CHUNG K; JEONG LAK-SHIN; BEACH J WARREN
权利人:UNIV GEORGIA RES FOUND
摘要:An asymmetric process for the preparation of enantiomerically pure β-L-(-)-1,3-oxathiolane-nucleosides that includes the initial preparation of the key chiral intermediates (2R,5R) and (2R,5S)-5-(O-protected)-2-(protected-oxymethyl)-1,3-oxathiolane from 1,6-thioanhydro-L-gulose. The 2R,5(R,S)-5-(O-protected)-2-(protected-oxymethyl)-1,3-oxathiolane is condensed with a desired heterocyclic base, typically a purine or pyrimidine base, to provide the product nucleoside. The synthesis can be used to prepare the pharmaceutically important compound, β-L-(-)-1-[(2β,4β)-2-(hydroxymethyl)-4-(1,3-thioxolane)]cytosine (β-L-(-)BCH-189).