CAS: 81633-29-6; Ethyl 2-Amino-4-Methylpyrimidine-5-Carboxylate

该化合物是一种火水衍生物,在制药和农用化学合成方面有很大的用途,其结构上有一个乙基酯组位于5点,一个氨基替代体位于2点,使其成为三环化合物开发的多用途中间体.四点的甲基组增强了核循环替代或凝聚反应的稳定性和影响反应的再活动性.该化合物因其定义明确的再活性特征和与多种合成途径的兼容性,对于制作活性药物成分和精细化学品特别有用.其晶体形式确保了始终的纯性,促进了研究和工业应用的复制结果.

结构式图片

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769-51-7 108123-81-5 19594-44-6

物理性质

MSDS等安全信息

欧盟法规

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上下游产品

CAS号188781-08-0 4-甲基-2-氯嘧啶-5-羧酸乙酯 | CAS号134653-70-6 2-Dimethylamino... | CAS号593-87-3 乙酸胍 | CAS号50-01-1 盐酸胍 | CAS号3788-94-1 2-乙氧亚甲基乙酰乙酸乙酯 | CAS号17994-55-7 6-甲基-2-氧代-1,2,3... | CAS号6214-64-8 4-甲基-2-羟基嘧啶-5-羧酸乙酯 | CAS号7234-25-5 4-甲基-2-甲硫基嘧啶-5-甲酸乙酯 | CAS号593-85-1 碳酸胍 | CAS号769-51-7 2-氨基-4-甲基嘧啶-5-甲酸 | CAS号108-52-1 2-氨基-4-甲基嘧啶

合成工艺路线路线简述

  • 141-97-9 + 4637-24-5 + 420-04-2 = 81633-29-6
    反应条件:1.1 Catalysts: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene Solvents: Benzene,Tetrahydrofuran; Reflux; 30 Min,Reflux
    标题:Dbu-Catalyzed,Aromatization-Oriented,Regioselective Domino Synthesis Of 2-Aminopyrimidines From β-Dicarbonyl Compounds,Dmf-Dma,And Cyanamide
    作者:Ungoren,Sevket Hakan; Et Al
    参考文献:Molecular Diversity 日期:2017 卷标:21(4) 页码:925-932]

    50-01-1 + 3788-94-1 = 81633-29-6
    反应条件:1.1 Reagents: Sodium Ethoxide Solvents: Ethanol; 1 H,Heated
    标题:Recyclization Reactions Of 1-Alkylpyrimidinium Salts
    作者:Vardanyan,Ruben S.; Et Al
    参考文献:Heterocyclic Communications 日期:2011 卷标:17 页码:129-133]

    141-97-9 + 61278-82-8 = 81633-29-6
    反应条件:1.1 Catalysts: Camphorsulfonic Acid Solvents: Dimethylformamide; 30 Min,80 °C2.1 Reagents: Sodium Methoxide Solvents: Ethanol; 10 Min,Rt2.2 Solvents: Tetrahydrofuran; 10 Min,130 °C
    标题:A "Catch And Release" Strategy For The Parallel Synthesis Of 2,4,5-Trisubstituted Pyrimidines
    作者:Porcheddu,Andrea; Et Al
    参考文献:Journal Of Combinatorial Chemistry 日期:2004 卷标:6(1) 页码:105-111]

    6214-64-8 = 81633-29-6
    反应条件:1.1 Reagents: Phosphorus Oxychloride; 30 Min,105 °C2.1 Reagents: Ammonia Solvents: Tetrahydrofuran; 45 Min,Rt
    标题:Facile Transformation Of Biginelli Pyrimidin-2(1H)-Ones To Pyrimidines. In Vitro Evaluation As Inhibitors Of Mycobacterium Tuberculosis And Modulators Of Cytostatic Activity
    作者:Singh,Kamaljit; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2011 卷标:46(6) 页码:2290-2294]

    17994-55-7 = 81633-29-6
    反应条件:1.1 Reagents: Pyridinium Chlorochromate2.1 Reagents: Phosphorus Oxychloride; 30 Min,105 °C3.1 Reagents: Ammonia Solvents: Tetrahydrofuran; 45 Min,Rt
    标题:Facile Transformation Of Biginelli Pyrimidin-2(1H)-Ones To Pyrimidines. In Vitro Evaluation As Inhibitors Of Mycobacterium Tuberculosis And Modulators Of Cytostatic Activity
    作者:Singh,Kamaljit; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2011 卷标:46(6) 页码:2290-2294]

    113-00-8 = 81633-29-6
    反应条件:1.1 Reagents: Sodium Methoxide Solvents: Ethanol; 10 Min,Rt1.2 Solvents: Tetrahydrofuran; 10 Min,130 °C
    标题:A "Catch And Release" Strategy For The Parallel Synthesis Of 2,4,5-Trisubstituted Pyrimidines
    作者:Porcheddu,Andrea; Et Al
    参考文献:Journal Of Combinatorial Chemistry 日期:2004 卷标:6(1) 页码:105-111]

    113-00-8 + 51145-57-4 = 81633-29-6
    反应条件:1.1 Reagents: Sodium Ethoxide Solvents: Ethanol
    标题:Reaction Of 2-Dimethylaminomethylene-1,3-Diones With Dinucleophiles. Viii. Synthesis Of Ethyl And Methyl 2,4-Disubstituted 5-Pyrimidinecarboxylates
    作者:Schenone,Pietro; Et Al
    参考文献:Journal Of Heterocyclic Chemistry 日期:1990 卷标:27(2) 页码:295-305]

    188781-08-0 = 81633-29-6
    反应条件:1.1 Reagents: Ammonia Solvents: Tetrahydrofuran; 45 Min,Rt
    标题:Facile Transformation Of Biginelli Pyrimidin-2(1H)-Ones To Pyrimidines. In Vitro Evaluation As Inhibitors Of Mycobacterium Tuberculosis And Modulators Of Cytostatic Activity
    作者:Singh,Kamaljit; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2011 卷标:46(6) 页码:2290-2294]

    113-00-8 + 3788-94-1 = 81633-29-6
    反应条件:1.1 Catalysts: Sodium Ethoxide
    标题:Recyclization Of 5-Carbethoxy-4-Methyl-2-Mercapto(Amino,Hydroxy)Pyrimidines To 5-Acetyl-2-Mercapto(Amino,Hydroxy)-4-Hydroxypyrimidines
    作者:Vartanyan,R. S.; Et Al
    参考文献:Khimiya Geterotsiklicheskikh Soedinenii 日期:1982 卷标:(11) 页码:1558-9
📜4-甲基-2-羟基嘧啶-5-羧酸乙酯置于氨,三氯氧磷体系中,用 四氢呋喃 作为反应溶剂,化学反应 1.25H,反应生成 2-氨基-4-甲基嘧啶-5-羧酸乙酯
参考文献:Facile Transformation Of Biginelli Pyrimidin-2(1H)-Ones To Pyrimidines. In Vitro Evaluation As Inhibitors Of Mycobacterium Tuberculosis And Modulators Of Cytostatic Activity
标题:Facile Transformation Of Biginelli Pyrimidin-2(1H)-Ones To Pyrimidines. In Vitro Evaluation As Inhibitors Of Mycobacterium Tuberculosis And Modulators Of Cytostatic Activity
摘要:A Series Of Pyrimidine Derivatives Bearing Amine Substituents At C-2 Position Were Obtained From Biginelli 3,4-Dihydropyrimidin-2(1H)-Ones And The Effect Of Structural Variation On Anti-Tb Activity Against Mycobacterium Tuberculosis H(37)Rv Strain And Antiviral Activity In A Series Of Cell Cultures Was Evaluated. While The Compounds Were Found To Possess Structure Dependent Cytostatic Activity,These Were Not Found To Be Efficient Inhibitors Of M. Tuberculosis Nor Did They Inhibit A Broad Variety Of Dna Or Rna Viruses In Cell Culture. (C) 2011 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2011.03.010

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合成参考文献


摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 213.
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