CAS: 80866-93-9; 2,2-Dimethyl-4-Oxo-3,4-Dihydro-2H-Pyran-6-Carboxylic Acid

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108799-25-3 520-45-6 5464-36-8

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CAS号108097-78-5 hydroxy-2 oxo-4...

📜4-甲基-3戊烯-2-酮置于盐酸体系中,用 四氢呋喃,乙醇,水 作为反应溶剂,化学反应 20.58H,反应生成 3,4-二氢-2,2-二甲基-4-氧代-2H-吡喃-6-羧酸
参考文献:无金属可见光介导的光催化:通过轴向手性控制分子内[2 + 2]烯酮的光环加成反应
标题:无金属可见光介导的光催化:通过轴向手性控制分子内[2 + 2]烯酮的光环加成反应
摘要:对分子特征为[2 + 2]的光环加成反应,评估了具有n-C芳基键旋转特性的对映异构烯酮-酰亚胺和烯酮-酰胺.观测到与交叉加成产物相比,直加成产物具有对反应性的非常好控制.发现阻转选择性取决于芳基环上的取代基.在不同的机理途径的基础上合理化了取代相关的阻转选择性.
DOI:10.1021/acs.Joc.6B01066

专利信息

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-2003082830-A1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:WO-0006525-A9
优先权日:1998-07-25
标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:WO-0006525-A2
优先权日:1998-07-25
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.