CAS: 75853-18-8; 2,3-Difluorobenzyl Alcohol

上下游产品

CAS号4519-39-5 2,3-二氟苯甲酸 | CAS号113211-94-2 2,3-二氟苄基溴

2,3-二氟苯甲酸置于diborane(6)体系中,用 四氢呋喃 作为反应溶剂,化学反应 1.5H,以40%的收率获得产物2,3-二氟苯甲醇
参考文献:9-(2-氟苄基)-6-(烷基氨基)-9H-嘌呤.一类新的抗惊厥药.
标题:9-(2-氟苄基)-6-(烷基氨基)-9H-嘌呤.一类新的抗惊厥药.
摘要:合成了抗惊厥嘌呤9-(2-氟苄基)-6-(甲基氨基)-9H-嘌呤(1)的几种取代的芳基和6-烷基氨基类似物,并测试了其对最大电击诱发癫痫发作(mes)的抗惊厥活性.在大鼠中.在芳基部分的5-或6-位具有第二个氟取代基的衍生物具有非常高的活性,Ip Ed50的范围为2-4 Mg / Kg.嘌呤6取代基在许多烷基氨基基团中发生变化的同类物对mes的有效活性与苯妥英相当或比苯妥英好几倍.
DOI:10.1021/jm00400A019

专利信息

专利号:US-5087764-A
优先权日:1988-03-10
标 题 :Process for the preparation of 2,3-difluorobenzenes
发明人：REIFFENRATH VOLKER; KRAUSE JOACHIM
权利人:MERCK PATENT GMBH
摘要:1,4-disubstituted 2,3-difluorobenzenes according to formula I are suitable as intermediates for the synthesis of liquid crystalline compounds.

专利号:CN-111303179-A
优先权日:2020-03-17
标 题:Synthesis of a Class of Norcantharidin Carboxylic Acid Difluorobenzyl Esters and Its Antitumor Application

专利号:CN-111303179-B
优先权日:2020-03-17
标 题 :Synthesis of norcantharidin carboxylic acid difluoro benzyl ester and anti-tumor application thereof

专利号:US-2008176865-A1
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:US-7645786-B2
优先权日:2005-06-15
标题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.