CAS: 74958-71-7; 2-[(3,5-Dinitrobenzoyl)Amino]-2-Phenyl-Acetic Acid

上下游产品

phenylglycin 3,5-dinitrobenoyl chloride(S)-(+)-N-(3,5-dinitrobenzoyl)-α-phenylglycine (R)-(-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine

📜2-氨基-2-苯基乙酸,3,5-二硝基苯甲酰氯 以 四氢呋喃 作为反应溶剂,化学反应 1.0H,以68%的收率获得产物n-3,5-二硝基苯甲酰-Dl-苯基甘氨酸
参考文献:对映体鉴别的可再生资源:异甘露醇和异山梨醇核磁共振光谱的手性溶剂化剂
标题:对映体鉴别的可再生资源:异甘露醇和异山梨醇核磁共振光谱的手性溶剂化剂
摘要:从异甘露醇和异山梨醇开始,在一个合成步骤中合成了一个新的手性选择剂家族,产率高达 84%.单或二取代氨基甲酸酯衍生物通过异己酯与给电子的芳基异氰酸酯(3,5-二甲基苯基-或3,5-二甲氧基苯基-)和吸电子芳基异氰酸酯(3,5-双(三氟甲基)苯基-)基团反应获得测试对映分化的相反电子效应.通过分别用 1-萘基异氰酸酯和对甲苯磺酰基异氰酸酯衍生得到更深的手性口袋和具有更多酸性质子的衍生物.在rac-N的1 H NMR 实验中,所有化合物均作为手性溶剂 (Csa) 进行了测试-3,5-二硝基苯甲酰基苯基甘氨酸甲酯,以确定不同结构特征对对映体识别能力的影响.一些选定的化合物与其他外消旋分析物进行了测试,仍会导致对映体歧视.然后针对最佳 Csa/分析物对优化对映体鉴别条件.最后,使用性能最佳的 Csa 与所选分析物的两种对映异构体进行 2D 和 1D-NMR 研究,旨在确定对映区分机制,相互作用的化学计量和络合常数.
DOI:10.1021/acs.Joc.2C01244

专利信息

专利号:US-5545568-A
优先权日:1992-09-14
标题:Solid phase and combinatorial synthesis of compounds on a solid support
发明人：ELLMAN JONATHAN A
权利人:UNIV CALIFORNIA
摘要:Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, β-turn mimetics and glycerol-derived drugs is described. In order to expediently synthesize such combinatorial libraries of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.

专利号:EP-2589587-A1
优先权日:2011-11-04
标题:Synthesis of nitrogen substituted cyclopropanes
发明人：RASPARINI MARCELLO; TADDEI MAURIZIO; CINI ELENA; MINELLI COSIMA; TURNER NICHOLAS; HUGENTOBLER KATHARINA GLORIA
权利人:CHEMO IBERICA SA
摘要:The invention is about a new synthetic pathway for the preparation of enantiomerically pure nitrogen substituted cyclopropanes, in particular the trans- cyclopropanamine ( 1 ), a key intermediate in the synthesis of Ticagrelor:n n The invention also relates to the processes for preparing said compounds or their salts and the use of said compounds as intermediates in preparing pharmaceutically active ingredients.

专利号:US-8981121-B2
优先权日:2010-06-25
标 题 :Process for the preparation of nitrogen substituted aminotetralins derivatives
发明人：ATES CELAL; SCHULE ARNAUD; PALACIO MAGALI; DEUTSCH PAUL; VASSELIN DAVID; CARLY NICOLAS; PHADTARE GANESH; YERANDE SWAPNIL; DELATINNE JEAN-PIERRE; ESCUDERO HERNANDEZ MARIA LUISA; PINILLA VERONIQUE
权利人:ATES CELAL; SCHULE ARNAUD; PALACIO MAGALI; DEUTSCH PAUL; VASSELIN DAVID; CARLY NICOLAS; PHADTARE GANESH; YERANDE SWAPNIL; DELATINNE JEAN-PIERRE; ESCUDERO HERNANDEZ MARIA LUISA; PINILLA VERONIQUE; UCB PHARMA GMBH
摘要:The present invention provides an alternative synthesis of N-substituted aminotetralines comprising resolution of N-substituted aminotetralins of formula (II), wherein R 1 , R 2 and R 3 are as defined for compound of formula (I).

专利号:US-7420070-B2
优先权日:2000-12-28
标 题:Process for preparing optically active 2,3-dihydrobenzofuran compounds
发明人：AOKI ISAO; ADACHI MARI; TAWADA HIROYUKI; YAMASHITA MAKOTO; SERA MISAYO
权利人:TAKODA PHARMACEUTICAL COMPANY
摘要:A process for preparing optically active 2,3-dihydrobenzofuran compounds which comprises subjecting a 2,3-dihydrobenzofuran compound represented by the general formula or a salt thereof to optical resolution with an optically active acid compound: n n[wherein R 1 and R 2 are each hydrogen or an optionally substituted hydrocarbon group; R 3 is an optionally substituted aromatic group; and C is a benzene ring which may further have a substituent in addition to the amino group]. The process enables industrially advantageous production of intermediates for the synthesis of optically active 2,3-dihydrobenzofuran compounds useful as preventive and/or therapeutic drugs for neurodegenerative diseases and so on.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-5288514-A
优先权日:1992-09-14
标题:Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support