专利号:US-6531591-B1 优先权日:1999-07-07 标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates 发明人:FENSHOLDT JEF 权利人:EXIQON AS 摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.
专利号:EP-1202998-B1 优先权日:1999-07-07 标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates 发明人:FENSHOLDT JEF 权利人:EXIQON AS 摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.
专利号:US-3983145-A 优先权日:1973-11-01 标 题:Use of alpha-di(lower alkoxy) anthraquinones in the synthesis of Alizarin Saphirols 发明人:WHITE DAVID L; FITZPATRICK JOSEPH W 权利人:TOMS RIVER CHEMICAL CORP 摘要:Alpha-dihydroxyanthraquinones used as intermediates in the synthesis of many dyestuffs, such as the Alizarin Saphirols (e.g. Color Constitution No. 63000, 63005, 63010, 63011, 63315 and 63610) can be replaced on an equimolar basis by alpha-di(lower alkoxy)anthraquinones. The alpha-di(lower alkoxy) anthraquinones can be converted in a single step, by treatment with oleum, to the corresponding alpha-dihydroxyanthraquinone-beta-disulfonic acids in almost quantitative yield. The corresponding diamine is obtained by dinitrating followed by reduction of the nitro groups. The known intermediate, leuco 1,4,5,8-tetrahydroxyanthraquinone (see C.I. No. 62500) can be obtained either by reduction of the diamine or by reduction of the dinitro compound. In one embodiment, the alpha-di(lower alkoxy)anthraquinone is obtained from dinitroanthraquinone by treatment thereof with methanol and KOH.
专利号:US-11738092-B2 优先权日:2019-12-04 标题:Methods and compositions for synthesis of therapeutic nanoparticles 发明人:WYENT EMILY A; BLUMENFELD CARL M; LAMM ROBERT J 权利人:DANTARI INC 摘要:Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.
专利号:US-8759508-B2 优先权日:2007-05-18 标 题 :Chromophoric silyl protecting groups and their use in the chemical synthesis of oligonucleotides 发明人:DELANEY MICHAEL OREN 权利人:DELANEY MICHAEL OREN; GE HEALTHCARE DHARMACON INC 摘要:The compounds are of class of chromophoric 1,2,3-triazolyl equipped silyl linking groups that are useful in the chemical synthesis of RNA. An example of a nucleoside comprising this group is
专利号:US-6712949-B2 优先权日:2001-07-22 标 题:Electrochemical synthesis of hydrogen peroxide 发明人:GOPAL RAMANATHAN 权利人:ELECTROSYNTHESIS CO INC 摘要:Improved methods and devices for the synthesis of hydrogen peroxide employing redox catalysts in a gas diffusion electrode or membrane electrode assembly in a semi-chemical/electrochemical system for the production of high purity, stable, usually acidic, aqueous solutions of peroxide at high conversion efficiencies without requiring organic solvents.
参考文献:10.1007/s00223-010-9337-4 摘要:McGregor NE, Poulton IJ, Walker EC, Pompolo S, Quinn JMW, Martin TJ, Sims NA. Ciliary Neurotrophic Factor Inhibits Bone Formation and Plays a Sex-Specific Role in Bone Growth and Remodeling. Calcified Tissue International. 2010 Feb 16;86(3):261–70. doi: 10.1007/s00223-010-9337-4. 参考文献:10.1186/1471-213x-10-16 摘要:Wood JL, Hughes AJ, Mercer KJ, Chapman SC. Analysis of chick (Gallus gallus) middle ear columella formation. BMC Developmental Biology. 2010 Feb 16;10(1):16. doi: 10.1186/1471-213x-10-16. 参考文献:10.1111/j.1600-0765.2011.01394.x 摘要:Lee YM, Shin SI, Shin KS, Lee YR, Park BH, Kim EC. The role of sirtuin 1 in osteoblastic differentiation in human periodontal ligament cells. J Periodontal Res. 2011 Dec;46(6):712–21. doi: 10.1111/j.1600-0765.2011.01394.x. 参考文献:10.1371/journal.pone.0021755 摘要:Huso DL, Edie S, Levine MA, Schwindinger W, Wang Y, Jüppner H, Germain-Lee EL. Heterotopic Ossifications in a Mouse Model of Albright Hereditary Osteodystrophy. PLoS ONE. 2011 Jun 29;6(6):e21755. doi: 10.1371/journal.pone.0021755. 参考文献:10.1007/s00774-011-0291-7 摘要:Burt-Pichat B, Follet H, Toulemonde G, Arlot M, Delmas P, Chapurlat R. Methodological approach for the detection of both microdamage and fluorochrome labels in ewe bone and human trabecular bone. Journal of Bone and Mineral Metabolism. 2011 Jul 13;29(6):756–64. doi: 10.1007/s00774-011-0291-7.