CAS: 5505-63-5; (2S,3R,4S,5R)-2-Amino-3,4,5,6-Tetrahydroxyhexanal Hydrochloride

该化合物是一种氨基糖和芒诺糖的衍生物,其特点是在C-2位置上存在一个有矿物质组(NH2)的衍生物,它看起来像一种白色的脱白晶粉,在水中溶解,适合各种生物应用;盐酸形式增强了其稳定性和溶性;D-Mannosami在甘油合成中发挥着关键作用,并参与了蜂窝过程,包括细胞信号和粘合;经常研究其潜在的治疗用途,特别是在免疫学和癌症研究领域,因为它能够影响细胞表面的相合模式;此外,它可以作为其他生物相关化合物合成的子质;与许多氨基糖一样,必须谨慎处理D-mannos 胺盐酸,并遵循适当的安全规程,因为它可能具有生物影响,需要具体情况下的进一步调查.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

N-acetyl-D-mannosamine 2-acetamido-1,2-dideoxy-1-nitro-D-mannitol 2-benzylamino-2-deoxy-D-mannononitrile 2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-mannoseD-glucaric acid D-glyceric acid D-erythronic acid arabinoic acid

合成工艺路线路线简述

    阿拉伯糖置于盐酸,乙醇,钯体系中,化学反应生成 盐酸 D-甘露糖胺
    参考文献:Kuhn; Jochims,Justus Liebigs Annalen Der Chemie,1959,Vol. 628,P. 172,181
    标题:Kuhn; Jochims,Justus Liebigs Annalen Der Chemie,1959,Vol. 628,P. 172,181

    海关参考信息

    专利信息


    专利号:US-2014349347-A1
    优先权日:2011-12-15
    标题:Synthesis of n-acetyl-d-neuraminic acid
    发明人:SCHROVEN ANDREAS; DEKANY GYULA; VRASIDAS IONNIS
    权利人:SCHROVEN ANDREAS; DEKANY GYULA; VRASIDAS IONNIS; GLYCOM AS
    摘要:Method of making NANA from NAM, which may itself be made from fructose. The NAM is treated with pyruvic acid or a pyruvate in the presence of a NANA aldolase having at least 70% sequence similarity or homology to the amino acid sequence of SEQ. ID. NO. 1.

    专利号:US-8076496-B2
    优先权日:2000-03-16
    标题:Chemoselective ligation
    发明人:SAXON ELIANA; BERTOZZI CAROLYN RUTH
    权利人:SAXON ELIANA; BERTOZZI CAROLYN RUTH; UNIV CALIFORNIA
    摘要:The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

    专利号:WO-2013088267-A1
    优先权日:2011-12-15
    标题 :Synthesis of n-acetyl-d-neuraminic acid

    专利号:EP-2791349-A1
    优先权日:2011-12-15
    标 题:Synthesis of n-acetyl-d-neuraminic acid

    专利号:CN-118979085-A
    优先权日:2023-05-11
    标 题 :Synthesis process of 9-azido-9-deoxy-N-glycolylneuraminic acid
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    主要参考文献

    1. Liu J, Numa MM, Liu H, Huang SJ, Sears P, Shikhman AR, Wong CH. Synthesis and high-throughput screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis. J Org Chem. 2004 Sep 17;69(19):6273-83. doi: 10.1021/jo049355h.

    合成参考文献


    参考文献:10.1007/bf02290581
    摘要:Kennedy JF. Selective detection and quantitative determination of the pentoses. Chromatographia. 1970 Jul;3(7):316–9. doi: 10.1007/bf02290581.
    参考文献:10.1007/978-1-4684-5209-9_1
    摘要:Bahl OP, Wagh PV. Characterization of Glycoproteins: Carbohydrate Structures of Glycoprotein Hormones. 1986. In: Molecular and Cellular Aspects of Reproduction. : Springer US; 1986.
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