CAS: 541-46-8; 3-Methylbutanamide

上下游产品

3-methylbutyric acid potassium thioacyanate Isovaleric anhydride methyl 3-methylbutanoate2,3,5,6-tetraphenylpyrazine 2-isobutyl-4-methylthiazole isovaleranilide 2-(isobutyl)benzoxazole

📜异戊酸置于n-甲基吗啉,氯甲酸异丁酯,Ammonium Hydroxide体系中,用 乙二醇二甲醚 作为反应溶剂,化学反应 14.25H,以70%的收率获得产物异戊酰胺
参考文献:基于铜介导的酰胺形成的合成包含脱氢缬氨酸和脱氢异亮氨酸的肽的研究.
标题:基于铜介导的酰胺形成的合成包含脱氢缬氨酸和脱氢异亮氨酸的肽的研究.
摘要:据报道制备了在抗生素粘多糖中存在的含有脱氢缬氨酸和脱氢异亮氨酸部分的肽片段.肽的形成基于酰基酰胺和肽基碘乙烯之间的铜介导的cn交叉偶联方案.在保护基的选择和反应条件方面,乙烯基碘中相邻精氨酸的存在提出了挑战.已发现鸟氨酸(一种合适的前体)比精氨酸更适合于实现cn交叉偶联反应的非常好收率.优化的条件用于以正确的立体化学合成含有相邻鸟氨酸的肽32,33,39和40以及含有脱氢异亮氨酸的三肽44.
DOI:10.3762/bjoc.12.55

专利信息

专利号:US-10253153-B2
优先权日:2015-04-24
标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
发明人：MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
权利人:NITTO DENKO CORP
摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

专利号:WO-9804535-A1
优先权日:1996-07-26
标 题 :A practical synthesis of benzoxazinones useful as hiv reverse transcriptase inhibitors
发明人：PIERCE MICHAEL ERNEST; RADESCA LILIAN ALICIA
权利人:DU PONT MERCK PHARMA
摘要:The present invention describes novel methods for the synthesis of benzoxazinone compounds which are useful as human immunodeficiency virus (HIV) reverse transcriptase inhibitors. The benzoxazinone of formula (VI-a) is particularly effective in the treatment of HIV.

专利号:WO-2011011342-A9
优先权日:2009-07-20
标题:Synthesis of desmopressin
发明人：SRIVASTAVA KRIPA S
权利人:MALLINCKRODT INC; SRIVASTAVA KRIPA S
摘要:The present invention provides a process for the production of desmopressin. In particular, the process provides a process for solid phase synthesis of desmopressin using cyclization of the peptide on the resin.

专利号:US-6794512-B2
优先权日:2001-11-02
标 题:Efficient synthesis of 5-heteroatom-containing -pyrazoles
发明人：SHAVNYA ANDREI; SAYKA SUBAS M; MINICH MARTHA L; RAST BRYSON
权利人:PFIZER
摘要:An efficient synthesis of sulfonyl pyrazoles of formula I: n wherein the ring of the formula (R 5 )-A-(SO m R 4 ), m, R 1 through R 9 are as defined in the specification, comprising reacting a compound of formula II: n wherein the ring of the formula (R 5 )-A-(SO m R 4 ), m R 1 through R 9 are as defined above and wherein R 10 is halo, (C 1 -C 6 )alkyl-SO 3 —, (C 6 -C 10 )aryl-SO 3 —, (C 1 -C 6 )alkyl-SO 2 —, or (C 6 -C 10 )aryl-SO 2 —; wherein each of said (C 1 -C 6 )alkyl component of said (C 1 -C 6 )alkyl-SO 3 — and (C 1 -C 6 )alkyl-SO 2 — radicals may optionally be substituted on any carbon atom by one to six fluoro substituents per (C 1 -C 6 )alkyl component; with a compound of formula R 3 —H, wherein R 3 is as defined above, in the presence of a fluoride containing salt and in the presence of a solvent.

专利号:US-3635999-A
优先权日:1969-03-25
标 题 :Synthesis of oxazoles
发明人：TRAMIER BERNARD; BONZOM ALBERT
权利人:AQUITAINE PETROLE
摘要:WHERE R2 IS ALKYL OF 1 TO 6 CARBON ATOMS, PHENYL OR HYDROXYPHENYL, R4 IS METHYL AND R5 IS HYDROGEN. A PROCESS OF PREPARING OXAZOLES IS DISCLOSED COMPRISING CONDENSING AN ACETYLENIC COMPOUND HAVING AN ELECTRONEGATIVE GROUP ON THE CARBON ATOM IN THE X-POSITION RELATIVE TO THE TRIPLE BOND WITH AN AMMONIUM SALT OF AN ORGANIC ACID OR AN AMIDE. 2-R2,4-R4,5-R5-OXAZOLE NEW OXAZOLES ARE PREPARED HAVING THE FORMULA

专利号:US-4161609-A
优先权日:1977-09-14
标题:Synthesis of carboxylic acid esters
发明人：CRAMER RICHARD D
权利人:DU PONT
摘要:A method is provided for converting a carboxylic acid amide to a carboxylic acid ester by reacting a vaporized mixture of the amide and an aliphatic alcohol or a phenol in the presence of a suitable catalyst at temperatures of from 100 DEG C. to 400 DEG C. The process is especially useful for the conversion of methacrylamide to methyl methacrylate.