CAS: 50606-32-1; Butyl Piperazine-1-Carboxylate

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120-43-4 37038-26-9 2138149-55-8

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CAS号1019928-96-1 4-benzyl-pipera... | CAS号1073554-07-0 piperazine-1,4-... | CAS号110-85-0 哌嗪 | CAS号592-34-7 氯甲酸正丁酯

📜氯甲酸丁酯置于palladium On Activated Charcoal,氢气,三乙胺体系中,用 乙醇,二氯甲烷 作为反应溶剂,化学反应生成 丁基哌嗪-1-羧酸
参考文献:Optimization Of 2-Phenyl-Pyrimidine-4-Carboxamides Towards Potent,Orally Bioavailable And Selective P2Y12 Antagonists For Inhibition Of Platelet Aggregation
标题:Optimization Of 2-Phenyl-Pyrimidine-4-Carboxamides Towards Potent,Orally Bioavailable And Selective P2Y12 Antagonists For Inhibition Of Platelet Aggregation
摘要:2-Phenyl-Pyrimidine-4-Carboxamide Analogs Were Identified As P2Y12 Antagonists. Optimization Of The Carbon-Linked Or Nitrogen-Linked Substituent At The 6-Position Of The Pyrimidine Ring Provided Compounds With Excellent Ex Vivo Potency In The Platelet Aggregation Assay In Human Plasma. Compound 23U Met The Objectives For Activity,Selectivity And Admet Properties.
DOI:10.1016/j.Bmcl.2014.06.070

专利信息

专利号:US-2024317784-A1
优先权日:2021-07-13
标题 :Process for the synthesis of 4-((r)-2-{[6-((s)-3-methoxy-pyrrolidin-1-yl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1-carboxylic acid butyl ester
发明人：BLUMER NICOLE; CLAVEAU ROMAIN; FEYEN FABIAN; HALL LEANNE; HUGHES STEPHEN; REBER STEFAN
权利人:VIATRIS ASIA PACIFIC PTE LTD
摘要:The present invention relates to a process for the synthesis of 4-((R)-2-{[6-((S)-3-methoxy-pyrrolidin-1-yl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1-carboxylic acid butyl ester, or of a hydrochloride salt thereof; and to a crystalline form of 4-((R)-2-{[6-((S)-3-methoxy-pyrrolidin-1-yl)-2-phenyl-pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1-carboxylic acid butyl ester hydrochloride.

专利号:WO-2014191548-A1
优先权日:2013-05-31
标题:New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
发明人：ZUPANCIC BORUT
权利人:LEK PHARMACEUTICALS
摘要:The present invention provides a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine), an experimental drug under development for the treatment of depression and anxiety, which comprises the reaction of a compound of formula (VII), or salt thereof, (VII) wherein Q represents S, SO or SO 2 and LG represents a leaving group, with a compound of formula (XI), or salt thereof, (XI) wherein Z represents hydrogen or a protecting group. New intermediate compounds are also provided.

专利号:US-9284344-B2
优先权日:2012-05-30
标题:Oligonucleotide synthesis method using highly dispersible liquid-phase support
发明人：KIM SHOKAKU; MATSUMOTO MASANORI
权利人:KIM SHOKAKU; MATSUMOTO MASANORI; HOKKAIDO SYSTEM SCIENCE CO LTD
摘要:A nucleic acid synthesis method enabling a reaction in a fluid (flow) with a highly dispersible liquid-phase support to improve coupling efficiency is provided. n The method for synthesizing an oligonucleotide comprising: sequentially condensing and oxidizing a nucleoside phosphoramidite compound in the presence of an acid/azole complex compound using a starting raw material, i.e., hydrophobic group-bonded nucleoside represented by Formula (1): n where R 1 : an alkylene group having 1 to 12 carbon atoms, R 2 : an alkylene group having 1 to 22 carbon atoms, R 3 and R 4 each independently represent an alkyl group having 1 to 22 carbon atoms or the like, R 5 : a single bond or an alkylene group having 1 to 22 carbon atoms, R 6 : each independently an alkyl group having 6 to 30 carbon atoms, n represents an integer of 2 to 6, X represents a hydrogen atom, hydroxyl group, or the like, Y: a protecting group deprotectable under an acidic condition, and Z: an adenyl group, a guanyl group, or the like having a polar group optionally protected by a protecting group,n wherein a condensation reaction is performed by preliminarily dissolving the hydrophobic group-bonded nucleoside or hydrophobic group-bonded oligonucleotide and the nucleoside phosphoramidite compound in a non-polar solvent, and contacting the resulting solution with the acid/azole complex compound or a solution containing the complex compound.

专利号:WO-2023285342-A2
优先权日:2021-07-13
标题 :A process for the synthesis of 4-((r)-2-{[6-((s)-3-methoxy-pyrrolidin-1-yl)-2-phenyl- pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1 -carboxylic acid butyl ester

专利号:EP-4370525-A2
优先权日:2021-07-13
标 题 :A process for the synthesis of 4-((r)-2-{[6-((s)-3-methoxy-pyrrolidin-1-yl)-2-phenyl- pyrimidine-4-carbonyl]-amino}-3-phosphono-propionyl)-piperazine-1 -carboxylic acid butyl ester

专利号:EP-1280780-A2
优先权日:2000-05-04
标 题:Asymmetric synthesis of piperazic acid and derivatives thereof