CAS: 495-07-8; 2-(Chloromethyl)-1,4-Difluorobenzene

上下游产品

2,5-二氟甲苯 2,5-Difluorotoluene 452-67-5
2-氟甲苯 2-Fluorotoluene 95-52-3

2-氟-5-硝基甲苯置于氯体系中,化学反应生成 2,5-二氟苄氯
参考文献:Jerumanis,S.; Bruylants,A.,Bulletin Des Societes Chimiques Belges,1960,Vol. 69,P. 312-322
标题:Jerumanis,S.; Bruylants,A.,Bulletin Des Societes Chimiques Belges,1960,Vol. 69,P. 312-322

专利信息

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including α-phenyl-β-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:US-7396846-B2
优先权日:2002-04-09
标题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA MARIA; TEBBE MARK JOSEPH
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:EP-0008532-A1
优先权日:1978-08-22
标 题 :Synthesis of amines

专利号:EP-0008532-B1
优先权日:1978-08-22
标 题 :Synthesis of amines

专利号:EP-0040896-A2
优先权日:1978-08-22
标 题 :Synthesis of amides