CAS: 402-49-3; 1-(Bromomethyl)-4-(Trifluoromethyl)Benzene

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CAS号455-24-3 4-三氟甲基苯甲酸 | CAS号349-95-1 4-(三氟甲基)苄醇 | CAS号583-02-8 4-(三氟甲基)苯甲酸乙酯 | CAS号329-15-7 对三氟甲基苯甲酰氯 | CAS号774197-61-4 3-(p-trifluorom... | CAS号455-19-6 对三氟甲基苯甲醛 | CAS号6140-17-6 4-甲基三氟甲苯 | CAS号402-51-7 4-三氟甲基苯基溴化镁 | CAS号455-19-6 对三氟甲基苯甲醛 | CAS号349-95-1 4-(三氟甲基)苄醇 | CAS号455-24-3 4-三氟甲基苯甲酸 | CAS号95088-20-3 N-(4-三氟甲基苄基)辛基溴化铵 | CAS号90390-11-7 N-甲基-4-三氟甲基苄胺 | CAS号22543-52-8 4,4'-BIS(TRIFLU... | CAS号207388-61-2 1-(iodomethyl)-... | CAS号195-19-7 苯并-3,4-菲 | CAS号613-33-2 4,4'-二甲基联苯 | CAS号538-39-6 1,2-二对甲苯基乙烷

溴甲苯置于tris(2,2-Bipyridine)Ruthenium(II) Hexafluorophosphate,三氟乙酸酐体系中,用 乙腈 作为反应溶剂,30.0 °C,101.33 Kpa 条件下,反应 15.0H,反应生成 1-溴-三氟对二甲苯
参考文献:用于位点选择性晚期三氟甲基化的芳基s盐.
标题:用于位点选择性晚期三氟甲基化的芳基s盐.
摘要:已经发现将cf 3基团掺入芳烃在药物发现中的重要性日益增加.在本文中,我们报道了芳基ian盐与铜基三氟甲基试剂的首次光氧化还原催化交叉偶联,这使得芳烃的位点选择性后期三氟甲基化成为可能.该反应以宽泛的官能团耐受性进行,即使对于克级的复杂小分子也是如此.该方法进一步扩展到生产五氟乙基化衍生物.
DOI:10.1002/anie.201906672

专利信息

专利号:US-9573939-B2
优先权日:2011-09-08
标题:Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; DANG QUN
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; DANG QUN; MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-7915276-B2
优先权日:2006-02-14
标题 :Berberrubine derivatives having antifungal activities
发明人：KIM SUNG UK; PARK KI DUK; MOON JAE SUN; KANG TAE HOON; KIM YOUNG KOOK
权利人:KOREA RES INST OF BIOSCIENCE
摘要:The present invention relates to a berberrubine derivative having superior antifungal activity, more particularly to a berberrubine derivative having activity against chitin synthase, which participates in the synthesis of chitin and is essential in the growth of fungi, and having a potent antifungal activity against human pathogenic fungi.

专利号:US-7816375-B2
优先权日:2000-09-11
标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof
发明人：AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:US-7812035-B2
优先权日:2001-12-11
标 题 :4-substituted piperidines, and methods of use thereof
发明人：RADEKE HEIKE; SHAO LIMING
权利人:SEPRACOR INC
摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

专利号:US-8193392-B2
优先权日:2005-07-29
标 题:Method for enantioselective synthesis of phosphorus-stereogenic phosphines
发明人：SCRIBAN CORINA; GLUECK DAVID S
权利人:SCRIBAN CORINA; GLUECK DAVID S; DARTMOUTH COLLEGE
摘要:The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.

专利号:US-4710513-A
优先权日:1979-08-17
标 题:Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.