CAS: 38136-70-8; (3S,8As)-3-((1H-Indol-3-yl)Methyl)Hexahydropyrrolo[1,2-A]Pyrazine-1,4-Dione

上下游产品

N-(tert-butoxycarbonyl)-D-proline L-tryptophan methyl ester 1-(tert-butoxycarbonyl)-L-proline (S)-tryptophan methyl ester hydr°Chloride(3S,8aR)-3-((2-(4-(trifluoromethyl)phenyl)-1H-indol-3-yl)methyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione deoxybrevianamide E 24H20BrF3N4O3C24H20BrF3N4O3 22H21BrN4O2C22H21BrN4O2

📜N-苄氧羰基-L-色氨酸置于5%-Palladium/activated Carbon,氢气,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺体系中,用 甲醇,二氯甲烷 用作溶剂,20.0 °C,506.66 Kpa 条件下,反应 26.0H,反应生成(3S,8As)-3-(1H-吲哚-3-基甲基)-2,3,6,7,8,8A-六氢吡咯并[2,1-F]吡嗪-1,4-二酮
参考文献:Beyond The Diketopiperazine Family With Alternatively Bridged Brevianamide F Analogues
标题:Beyond The Diketopiperazine Family With Alternatively Bridged Brevianamide F Analogues
摘要:A Method For The Preparation Of 3,5-Bridged Piperazin-2-Ones From A Tryptophan Proline-Based Diketopiperazine Is Described Using Diphosgene To Induce The Ring Closure. Density Functional Theory Calculations Were Conducted To Study The Mechanism Of This C-C Bond Formation. Several Derivatives Of The Thus Obtained Alpha-Chloroamine Were Synthesized By Substitution Of The Chlorine Atom Using A Range Of O-,N-,S-,And C-Nucleophiles. This Novel Class Of Brevianamide F Analogues Possess Interesting Breast Cancer Resistance Protein Inhibitory Activity.
Doi:10.1021/acs.Joc.5B01161

专利信息

专利号:US-7723082-B2
优先权日:2002-06-21
标题 :Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives
发明人：GONDRY MURIEL; GENET ROGER; LAUTRU SYLVIE; PERNODET JEAN-LUC
权利人:COMMISSARIAT ENERGIE ATOMIQUE; CENTRE NAT RECH SCIENT
摘要:The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides and diketopiperazine derivatives 3- and 6-substituted by α,β-unsaturated amino acid side chains.

专利号:US-2006051837-A1
优先权日:2002-06-21
标 题 :Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives

专利号:US-2007048817-A1
优先权日:2002-06-21
标 题:Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives

专利号:AU-2003255681-B2
优先权日:2002-06-21
标题:Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives

专利号:AU-2003255681-A1
优先权日:2002-06-21
标题 :Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives