CAS: 365-26-4; (R*,S*)-4-Hydroxy-α-[1-(Methylamino)Ethyl]Benzyl Alcohol

上下游产品

CAS号132224-98-7 1-(4-hydroxy-ph... | CAS号770-39-8 4-羟基苯基丙酮

📜2-(Benzyl-Methyl-Amino)-1-(4-Benzyloxy-Phenyl)-Propan-1-One 在 乙醇,钯体系中,获得 Oxilofrine
参考文献:De581331
标题:De581331

专利信息

专利号:US-8017776-B2
优先权日:2003-07-15
标题 :Methods for synthesis of acyloxyalkyl compounds
发明人：BHAT LAXMINARAYAN; GALLOP MARK A
权利人:XENOPORT INC
摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

专利号:US-8143437-B2
优先权日:2002-02-19
标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
发明人：GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X
权利人:GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X; XENOPORT INC
摘要:The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.

专利号:US-2005070715-A1
优先权日:2003-07-15
标 题:Methods for synthesis of acyloxyalkyl compounds

专利号:US-7560483-B2
优先权日:2002-02-19
标题 :Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof

专利号:US-7662987-B2
优先权日:2003-07-15
标题:Methods for synthesis of acyloxyalkyl compounds

专利号:US-2003171303-A1
优先权日:2002-02-19
标 题 :Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof