CAS: 356560-80-0; 6-Bromo-[1,2,4]Triazolo[1,5-A]Pyridine

该化合物是一种环球化合物,其组成为三甲苯-核心,具有溴替代成分,这种结构将多功能作为制药和农用化学合成的关键中间体,特别是在开发活性成分方面.溴原子提供了一个反应反应的被动站点,通过相互交织的结合,如Suzuki 或 Buchwald-Hartwig 组合,进一步发挥作用,从而能够进行精确的结构改变. 在标准条件下,它稳定且与各种反应条件相容,使它成为医药化学和材料科学应用的可靠建筑块.该化合物定义明确的再活动特征可以确保复杂的合成路径的一贯性.

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CAS号138888-98-9 N'-(5-溴吡啶-2-基)-... | CAS号1075260-65-9 N-(5-bromo-2-py... | CAS号1072-97-5 2-氨基-5-溴吡啶 | CAS号1160790-18-0 9-氮杂吲哚-5-硼酸频哪醇酯 | CAS号943845-23-6 [1,2,4]三唑并[1,5-...

合成工艺路线路线简述

    📜N-(5-Bromo-2-Pyridinyl)Imidoformamide置于吡啶,Hydroxylamine-O-Sulfonic Acid体系中,用 甲醇 作为反应溶剂,化学反应生成 6-溴-[1,2,4]三唑并[1,5-A]吡啶
    参考文献:Wo2008/128953
    标题:Wo2008/128953

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    专利信息


    专利号:US-2012077802-A1
    优先权日:2009-06-10
    标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
    发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
    权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
    摘要:Provided herein are spiro-cyclic compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

    专利号:US-8404670-B2
    优先权日:2009-02-11
    标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
    发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
    权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
    摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

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    合成参考文献

    参考DOI号:10.1002/ej°C.200500247
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