CAS: 3306-52-3; (+/-)-Viridin

该化合物是一种自然形成的化合物,被归类为二级代谢物,主要来自某些真菌物种,特别是类中的真菌.Viridin以其独特的绿色颜色而著称,这归因于其独特的化学结构.该复合物展示了一系列生物活动,包括抗风和抗菌特性,使其对制药研究感兴趣.其结构具有碳,氢和氧原子的复杂安排,有助于其再活动以及与生物系统的互动.Viridin的溶性特征可以变化,影响其生物利用率和药用化学的潜在应用.此外,正在进行的研究正在探索其在植物-风相互作用中的作用及其作为天然杀虫剂的潜力.总的来说,Viridin是天然产品化学中一个令人感兴趣的研究领域,对生态和治疗应用都有影响.

结构式图片

MSDS等安全信息

    合成工艺路线路线简述

      📜(5Br,6S,7S)-6-(1-Ethoxy-Ethoxy)-7-Methoxy-5B-Methyl-1,2,6,7-Tetrahydro-5Bh-10-Oxa-Cyclopenta[j]Acephenanthrylene-3,8,11-Trione置于4-甲基苯磺酸吡啶体系中,用 甲醇 用作溶剂,化学反应 2.0H,以84%的收率获得(1S-(1Alpha,2Alpha,11Balpha))-1,7,8,11B-四氢-1-羟基-2-甲氧基-11B-甲基环戊并(7,8)菲并(10,1-Bc)呋喃-3,6,9(2H)-三酮
      参考文献:呋喃类固醇抗生素viridin的合成.
      标题:呋喃类固醇抗生素viridin的合成.
      摘要:
      Doi:10.1002/anie.200353129

      海关参考信息

      专利信息


      专利号:WO-2008151636-A1
      优先权日:2007-06-14
      标题:Synthesis of mycophenolic acid (mpa)

      专利号:US-2010190238-A1
      优先权日:2007-06-14
      标题 :Synthesis of mycophenolic acid (mpa)

      专利号:EP-2155879-A1
      优先权日:2007-06-14
      标题 :Synthesis of mycophenolic acid (mpa)

      专利号:CN-106852496-A
      优先权日:2015-12-09
      标题:Method for inducing synthesis of triterpenes contained in mushrooms

      专利号:CA-2690241-A1
      优先权日:2007-06-14
      标题:Synthesis of mycophenolic acid (mpa)

      专利号:US-7199128-B2
      优先权日:2005-02-02
      标题 :8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
      发明人:BRADBURY BARTON J; WILES JASON ALLAN; DESHPANDE MILIND; WANG QIUPING; HASHIMOTO AKIHIRO; LUCIEN EDLAINE
      权利人:ACHILLION PHARMACEUTICALS INC
      摘要:The invention provides compounds and salts of Formula I and Formula II: n nwhich possess antimicrobial activity. The invention also provides novel synthetic intermediates useful in making compounds of Formula I and Formula II. The variables A 1 , A 8 , R 2 , R 3 , R 5 , R 6 , R 7 , and R 9 are defined herein.n n Certain compounds of Formula I and Formula II disclosed herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of compounds of Formula I and/or Formula II and one or more other active agents. The invention also provides methods for treating microbial and protozoal infections in animals.

      供应商参考报价(招募中)

      品牌试剂参考报价(招募中)

      📌 第三方产品分析报告

      ✅ COA系统入驻 | 共享模式

      主要参考文献


      1: Jones RW, Hancock JG. Conversion of viridin to viridiol by viridin-producing fungi. Can J Microbiol. 1987 Nov;33(11):963-6. doi: 10.1021/jacs.9b08577. Epub 2019 Oct 3. doi: 10.1021/jacs.7b02829. Epub 2017 May 12.
      5: Pollastro F, Caprioglio D, Marotta P, Moriello AS, De Petrocellis L, Taglialatela-Scafati O, Appendino G. Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids. J Nat Prod. 2018 Mar 23;81(3):630-633. doi: 10.1021/acs.jnatprod.7b00946. Epub 2017 Dec 14.
      7: Andersson PF, Bengtsson S, Cleary M, Stenlid J, Broberg A. Viridin-like steroids from Hymenoscyphus pseudoalbidus. Phytochemistry. 2013 Feb;86:195-200. doi: 10.1016/j.phytochem.2012.09.012. Epub 2012 Oct 22. doi: 10.1158/1535-7163.MCT-08-1012. Epub 2009 Jun 9.

      合成参考文献


      参考文献:10.1021/ol061697h
      摘要:Sessions EH, Jacobi PA. Studies on the synthesis of furanosteroids. I. Viridin models. Org Lett. 2006 Aug 31;8(18):4125–8. doi: 10.1021/ol061697h.
      参考文献:10.1007/s11302-008-9111-5
      摘要:García-Echeverría C. Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways. Purinergic Signalling. 2008 Jun 04;5(1):117–25. doi: 10.1007/s11302-008-9111-5.
      📝 需求与反馈
      尽可能描述清楚需求与问题信息
      ×

      通知