CAS: 2927-34-6; 1,2-Difluoro-4-Methylbenzene

上下游产品

CAS号455-86-7 3,4-二氟苯甲酸 | CAS号32133-36-1 DL-3,4-二氟苯丙氨酸 | CAS号34036-07-2 3,4-二氟苯甲醛 | CAS号85118-01-0 3,4-二氟溴苄 | CAS号875664-38-3 2-溴-4,5-二氟甲苯 | CAS号127371-50-0 2-硝基-4,5-二氟甲苯

1,1,2-三氟-2-氯-3-甲基-3-乙烯基环丁烷 反应 1.0H,以44%的收率获得3,4-二氟甲苯
参考文献:从三氟氯乙烯和丁-1,3-二烯两步区域选择性合成1,2-二氟苯
标题:从三氟氯乙烯和丁-1,3-二烯两步区域选择性合成1,2-二氟苯
摘要:三氟氯乙烯与丁-1,3-二烯,戊-1,3-二烯或异戊二烯在流动反应器中于 440-480oc 的气相共解得到 4-氯-4,5,5-三氟环己-1-Enes.后者在相转移催化条件下用 Koh 水溶液选择性地转化为 1,2-二氟苯,2,3-二氟甲苯或 3,4-二氟甲苯.
Doi:10.1007/s11172-020-2724-8

专利信息

专利号:US-2013172553-A1
优先权日:2009-11-25
标题 :Chiral synthesis of isoxazolines, isoxazoline compounds, and uses thereof
发明人：SIELECKI-DZURDZ THAIS; PRUITT JAMES
权利人:SIELECKI-DZURDZ THAIS; PRUITT JAMES; CPSI STOCKHOLDER TRUST
摘要:Processes for the chiral syntheses of isoxazolines and intermediates are described. Compounds prepared thereby, and methods of using the compounds are also described.

专利号:US-2018148745-A1
优先权日:2015-05-26
标题:Hemoprotein catalysts for improved enantioselective enzymatic synthesis of ticagrelor
发明人：ARNOLD FRANCIS H; RENATA HANS; MCINTOSH JOHN A; LEWIS RUSSELL D; KAN SEK BIK JENNIFER; HERNANDEZ KARI; COELHO PEDRO; ROZZELL DAVID; ZHANG CHEN
权利人:CALIFORNIA INST OF TECHN; PROVIVI INC
摘要:The present invention provides methods by which trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine and related cyclopropane compounds are prepared using synthetic strategies that include a biocatalytic cyclopropanation step.

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:WO-2015067230-A1
优先权日:2013-11-08
标题 :A production method and a new crystalline form of an intermediate of synthesis of ticagrelor
发明人：VOSLAR MICHAL; STRELEC IVO; DAMMER ONDREJ; VYSLOUZIL ROSTISLAV; STEHLĺČEK, Ivan; RIHA JAROSLAV; HES TOMAS; OBADALOVA IVA
权利人:ZENTIVA KS
摘要:The invention relates to preparation of ticagrelor of formula I and comprises a reaction of a compound of formula IV with a deprotection agent in a solvent to a compound of formula V, which is advantageously isolated by crystallization and subsequently used for the preparation of ticagrelor. The substituent R in formulae IV and V is CH 2 CH 2 OH, CH 2 COOH, or CH 2 COOR 1 ; R 1 is a branched or unbranched R1-C4 alkyl; and X is NH 2 , NO 2 f or NHCHO.

专利号:WO-2018109082-A1
优先权日:2016-12-15
标题 :Process and intermediate for the preparation of 1-(4-(2-((1-(3,4- difluorophenyl)-1h-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone
发明人：ALMANSA ROSALES CARMEN; CAAMAÑO MOURE ANA MARÃ?A; ENJO BABÃ?O JUAN
权利人:ESTEVE LABOR DR
摘要:The present invention relates to a process for the preparation of 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone and salts and solvates thereof and to the use of intermediates in the synthesis of these compounds. Also is provided a new intermediate compound.

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.