CAS: 2623-33-8; 4-Acetamidophenyl Acetate
该化合物是一种有机化合物,其特点是其乙酰和乙酰胺功能组;一种白色的,白白的晶状固体,在有机溶剂中溶解,但在水中溶解性有限;该化合物主要用于药物应用,通常作为合成止痛剂和抗呼吸剂的中间体;其结构特征是一个乙酰氧基组,它附属于一种乙酰胺细胞,有助于其生物活动. 丙氧乙酰氨酰胺展示类似于丙酰胺的特性,包括止痛作用和降低发烧作用,尽管其具体的药特征可能有所不同.该化合物应谨慎处理,因为如果摄入或吸入,可能会对健康造成危害,在实验室或工业环境中使用适当的安全措施时应观察到.
- 英文名称4-Acetamidophenyl Acetate
- 中文名称醋酸对乙酰氨基酚(对乙酰氨基酚杂质)
- IUPAC名称4-acetamidophenyl acetate
- 其它别名Acetanilide,4'-hydroxy-, acetate (6CI,7CI); Acetanilide, 4'-hydroxy-, acetate (ester)(8CI); 4-Acetamidophenyl acetate; 4'-Acetoxyacetanilide; Acetaminophen acetate; Diacetamate; N-(4-Acetoxyphenyl)acetamide; N-Acetyl-4-aminophenyl acetate; O-Acetylparacetamol; p-Acetamidophenyl acetate; p-Acetoxyacetanilide
- CAS编号2623-33-8
- MFCD编号:MFCD00059205
- EINECS号:220-077-6
- FDA UNII编号:BFG1TY61BG
- 分子式:C10H11NO3分子量:193.2
- 产品CID: 1233352
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
物理性质
- 熔点155 °C
- 沸点329.41 °C at 760 mmHg
- 闪点181.4±23.2 °C
- 密度1.2±0.1 g/cm3
- pKa:14.41±0.70(预测)
- PSA:55.4
- LogP:1.5703
- 折射率1.561
- 蒸汽压0.0±0.9 mmHg at 25°C
- 溶解性Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- 敏感性如果遵照规格使用和储存则不会分解。
- 外观形态白色至类白色固体
- 储存条件密封干燥,冷冻保存, 低于 -20°C
- 产品应用该化合物是一种乙酰氨酚合成杂质. 丙氨基苯-草皮混合物由于前者的乙酰胺化,产生二乙基苯丙胺-P-氨基酚,因此稳定性较低.
MSDS等安全信息
欧盟法规
REACH注册ECHA物质C&L通报REACH预注册上下游产品
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📜4-Acetyloxyacetophenone Oxime置于碘体系中,用 乙腈 用作溶剂,化学反应 4.0H,以88%的收率获得乙酰胺基苯酚乙酸酯
参考文献:轻度中性条件下碘对酮介导的贝克曼重排成酰胺的作用
标题:轻度中性条件下碘对酮介导的贝克曼重排成酰胺的作用
摘要:芳基酮肟易于进行贝克曼重排,在无水乙腈中回流下,由元素碘进行亲电子活化,以优异的收率获得n-取代的酰胺.该环境友好方案的主要优点包括由于没有伴随的脱保护而形成副产物母体酮的高选择性,温和的中性条件,操作简便以及特别易于分离产物. 重排-酰胺-酮肟-催化-贝克曼重排
Doi:10.1055/s-0030-1258217
海关参考信息
- 2912110000-甲醛
2912120000-乙醛
2915110000-甲酸
2915211900-乙酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2022228297-A1
优先权日:2021-04-26
标 题:Enzymatic preparation technique for acyl/aroyl coenzyme a
发明人：ZHU PING; ZHANG BOYONG; WANG HAO; GONG TING; CHEN TIANJIAO; CHEN JINGJING; YANG JINLING
权利人:INST OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCICENCES
摘要:Provided are a method for large-scale preparation of acyl/aroyl coenzyme A by an enzymatic method, i.e., using an acyltransferase to transfer acyl/aroyl from a cheap acyl/aroyl donor onto acyl/aroyl receptor coenzyme A, thereby achieving large-scale synthesis of acyl/aroyl coenzyme A, and a use of the method in the preparation of acyl/aroyl coenzyme A.
专利号:US-9006488-B1
优先权日:2014-03-20
标 题 :Solvent free synthesis of acetaminophen
发明人：AMIN MUHAMMAD; IQBAL MUHAMMAD S
权利人:AMIN MUHAMMAD; IQBAL MUHAMMAD S
摘要:A solvent-free mechanical process of reacting amine compounds with acetylating agents resulting in amides such as acetaminophen is described.
专利号:US-2006128939-A1
优先权日:2004-12-03
标题 :One pot process for making polymeric antioxidants
发明人：KUMAR VIJAYENDRA; YANG SUIZHOU; CHOLLI ASHOK L
权利人:KUMAR VIJAYENDRA; YANG SUIZHOU; CHOLLI ASHOK L
摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes mono-deacetylating, polymerizing and deacetylating an aryl monomer represented by the following structural formula: n n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
专利号:US-9499465-B2
优先权日:2013-03-15
标题 :Synthesis of biobased and substituted terephthalic acids and isophthalic acids
发明人：FROST JOHN W
权利人:UNIV MICHIGAN STATE
摘要:Methods for producing bio-terephthalic acid and bio-isophthalic acid are provided. The methods comprise a cycloaddition reaction to produce bio-4-methyl-3-cyclohexene-1-carboxylic acid, and bio-3-methyl-3-cyclohexene-1-carboxylic from bio-isoprene and bio-acrylic acid. An aromatization reaction produces bio-para-toluic acid and bio-meta-toluic acid from the bio-4-methyl-3-cyclohexene-1-carboxylic acid, and bio-3-methyl-3-cyclohexene-1-carboxylic. An oxidation reaction produces the bio-terephthalic acid and iso-phthalic acid from the bio-para-toluic acid and bio-meta-toluic acid.
专利号:US-2016031787-A1
优先权日:2013-03-15
标 题 :Synthesis of biobased and substituted terephthalic acids and isophthalic acids
专利号:CN-119707712-A
优先权日:2024-12-06
标题 :A kind of synthesis process of trans-p-aminocyclohexanol
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Thomis R, Roets E, Hoogmartens J. Analysis of tablets containing aspirin, acetaminophen, and ascorbic acid by high-performance liquid chromatography. J Pharm Sci. 1984 Dec;73(12):1830-3. doi: 10.1002/jps.2600731246. 100(10):1043-7. Japanese. doi: 10.1248/yakushi1947.100.10_1043.
合成参考文献
摘要:Ros, A.; Fernández, R.; Lassaletta, J. M., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 431.
摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129.
参考文献:10.1002/jps.10127
摘要:Jouyban A, Rehman M, Shekunov BY, Chan H, Clark BJ, York P. Solubility Prediction in Supercritical CO2 Using Minimum Number of Experiments. Journal of Pharmaceutical Sciences. 2002 May;91(5):1287–95. doi: 10.1002/jps.10127.
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