CAS: 2592-95-2; 1-Benzotriazolol(Hobt)

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CAS号98-95-3 硝基苯 | CAS号88-73-3 邻氯硝基苯 | CAS号288315-03-7 3,3-二氟三甲叉亚胺盐酸盐 | CAS号94790-37-1 苯并三氮唑-N,N,N',N'... | CAS号2075-46-9 4-硝基吡唑 | CAS号3034-19-3 2-硝基苯肼 | CAS号856698-55-0 9-methoxy-2,3-d... | CAS号74-89-5 氨基甲烷 | CAS号22713-34-4 1H-Benzotriazol... | CAS号55-21-0 苯甲酰胺 | CAS号22713-34-4 1H-Benzotriazol... | CAS号617-94-7 2-苯基-2-丙醇 | CAS号50349-73-0 | CAS号2867-65-4 1,3-Butanediol,... | CAS号235112-66-0 1H-苯并[d][1,2,3]... | CAS号82911-71-5 1-[(9H-芴-9-基甲氧基... | CAS号77716-16-6 B°C-4-氨基-1-甲基吡咯... | CAS号88544-01-8 双(1-苯并[d]三咪唑)碳酸酯 | CAS号13351-73-0 1-甲基-1H-苯并三唑

硝基氯苯置于一水合肼体系中,用 乙醇 用作溶剂,化学反应 20.0H,反应生成1-羟基苯并三唑
参考文献:N-芳基苯并三唑类氮氧衍生物及其合成方法
标题:N-芳基苯并三唑类氮氧衍生物及其合成方法
摘要:本发明公开了一系列n‑芳基苯并三唑类氮氧衍生物及其合成方法.本发明所述的n‑芳基苯并三唑类氮氧衍生物具有如下式(I)所示结构,其制备方法为:取下述式(II)所示结构的n‑羟基苯并三唑衍生物,式(III)所示结构的有机硼试剂,铜盐和碱性物质,置于有机溶剂中,在氧气存在的条件下反应,制得目标物粗品.本发明所述方法简单易控,周期短;制得的部分n‑芳基苯并三唑类氮氧衍生物具有非常好的抗肿瘤活性.所述式(I),式(II)和式(III)所示结构的化合物分别如下:.

专利信息

专利号:WO-2024185734-A1
优先权日:2023-03-03
标 题:Polyphosphorylated nucleoside, phosphate-activated nucleotide used for synthesis of polyphosphorylated nucleoside and method for synthesis of same, and method for synthesis of polyphosphorylated nucleoside using phosphate-activated nucleotide
发明人：KATAOKA MASANORI; FUKUI CHIHARU; TSUJI YOHEI; FUJIMURA Kazuma
权利人:NATIAS INC
摘要:The present invention provides: a polyphosphorylated nucleoside which has a structure represented by formula (I) and can be efficiently produced by a short process and a simple operation with use of a less expensive material; a phosphate-activated nucleotide which is used for the synthesis of the polyphosphorylated nucleoside and a method for the synthesis of this phosphate-activated nucleotide; and a method for the synthesis of a polyphosphorylated nucleoside using a phosphate-activated nucleotide. In the formula, B represents a protected or unprotected, natural or artificial nucleoside base; R 1 , R 2 , R 4 and R 5 each represent H or an alkyl group or the like, and R 1 , R 2 , R 4 and R 5 may be the same as or different from each other; X and Y each represents H, OH, OCH 3 or the like; h represents an integer of 1 to 3; p, n, m and q each represent 0 or an integer, and p, n, m and q are in no particular order; and (p + n + m + q) is an integer of 0 to 5,000.

专利号:US-11466050-B2
优先权日:2014-09-29
标 题 :Method for peptide synthesis and apparatus for carrying out a method for solid phase synthesis of peptides
发明人：KNAUER SASCHA; ROESE TOBIAS MICHAEL LOUIS; AVRUTINA OLGA; KOLMAR HARALD; UTH CHRISTINA
权利人:SULFOTOOLS GMBH
摘要:The invention relates to a method for peptide synthesis, wherein said method comprises the steps of reacting a first amino acid or a first peptide with an α-amine protected second amino acid in a solvent selected from the group consisting of water, alcohol, and a mixture of water and alcohol, and removing the α-amine protecting group with a deprotecting solution. The invention further relates to protective agents, their use and an apparatus for carrying out a method for solid phase synthesis of peptides.

专利号:WO-2023030277-A1
优先权日:2021-08-30
标 题:Method for fully liquid-phase synthesis of grnh nonapeptide amide analog
发明人：SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN
权利人:HUNAN MICRO PEPTIDE BIOMEDICAL CO LTD
摘要:Provided is a method for fully liquid-phase synthesis of a GRnH nonapeptide amide analog, which belongs to the technical field of medicine synthesis. The method comprises respectively synthesizing a 'Trp-Ser-Tyr' fragment, an 'R-Leu' fragment, a 'Pyr-His' fragment and 'Arg-Pro-Hunan T', wherein, R = D-Ala (alarelin), D-Leu (leuprorelin), D-Trp (deslorelin) and D-His (histrelin), and obtaining the GRnH nonapeptide amide analog with high yield and high purity by means of a '3 +2 +2 +2' fragment condensation method. The synthesis method is environmentally friendly, mild, and free of any highly toxic and poisonable reagents. The cost is greatly reduced and the synthesis method is very suitable for large-scale production.

专利号:WO-2024181781-A1
优先权日:2023-02-27
标 题:Substrate for synthesis of biological polymers having anti-aggregation function and biological polymer synthesis method using same
发明人：JANG MYOUNG HOON; CHOI JAE SUN
权利人:SP2 TX INC
摘要:The present invention relates to a substrate for the synthesis of biological polymers having an anti-aggregation function, and a biological polymer synthesis method using the substrate. The substrate according to an aspect may have anti-aggregation functionality to enable high-yield and high-purity processes in the synthesis of biological polymers.

专利号:WO-2023012709-A1
优先权日:2021-08-05
标 题 :An improved process for fmoc synthesis of semaglutide
发明人：LOBO LESTER JOHN; CHANDRAKESAN MURALIDHARAN; DOSHI CHETAN; CHANADAK SHAILESH LALCHAND; YADAV NANDLAL GOPAL; MOHE NIKHIL UMESH; VISHWANATHAN KODANDARAMAN
权利人:USV PRIVATE LTD
摘要:The present invention relates to an improved process for the synthesis of glucagon-like-peptide-1 (GLP-1) and its analogs by using combination of solid and solution phase synthesis of Fmoc protected amino acids in a sequential manner, optionally incorporating Boc protected dipeptide for unnatural amino acid in the Sequence of GLP-1, cleaving GLP-1 sequence from the resin followed by purification; attaching side-chain to the desired amino acid in the solution phase to synthesize desired GLP-1 analog, purifying it to Semaglutide. Temperature gradient is applied during initial coupling of amino acids to facilitate completion of difficult coupling reactions.

专利号:WO-2024151344-A9
优先权日:2022-11-18
标题:A device that enables the combinatorial synthesis of small molecule libraries
发明人：COPELAND Gregory; LIU JANE
权利人:BRT BIOTECHNOLOGIES INC
摘要:A device for the synthesis of small molecules on a substrate is provided. The device includes a synthesis plate with vias, and a microfluidic patterning plate with a series ot open-faced channels that can be aligned with the vias on the synthesis plate. The device may be used to synthesize combinatorial libraries of small molecules.