CAS: 20922-03-6; 1-Isopropylisoquinoline

相似化合物

2341906-98-5 7661-60-1 1721-94-4

上下游产品

isoquinoline 1-methyl-3,4,dihydroisoquinoline 1-isopropyl-1,2,3,4-tetrahydroisoquinoline (S)-1-isopropyl-1,2,3,4-tetrahydroisoquinoline (R)-1-isopropyl-1,2,3,4-tetrahydroisoquinoline (R)-(+)-6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline

📜1-异丙基-1,2,3,4-四氢异喹啉置于c21H21Clirno2体系中,用 四氢呋喃,2,2,2-三氟乙醇 用作溶剂,化学反应 20.0H,以92%的收率获得1-异丙基异喹啉
参考文献:多功能铱催化剂对氮杂环进行无受体脱氢
标题:多功能铱催化剂对氮杂环进行无受体脱氢
摘要:放气:发现一种环金属化的铱络合物可催化各种苯并稠合的n-杂环的脱氢反应,从而释放出h 2.在低至0.1 Mol%的催化剂的驱动下,该反应可高产率提供喹啉,吲哚,喹喔啉,异喹啉和β-咔啉.
Doi:10.1002/anie.201300292

专利信息

专利号:US-9650341-B2
优先权日:2010-05-04
标 题 :Process for synthesizing oxidized lactam compounds
发明人：REMENAR JULIUS F; BLUMBERG LAURA COOK; ZEIDAN TAREK A
权利人:ALKERMES PHARMA IRELAND LTD
摘要:The invention provides a method for the synthesis of dehydrogenated lactam drugs of Formula I:

专利号:US-8754237-B2
优先权日:2006-02-14
标题:Bifunctional histone deacetylase inhibitors
发明人：BRADNER JAMES ELLIOT; MAZITSCHEK RALPH; TANG WEIPING; SCHREIBER STUART L
权利人:BRADNER JAMES ELLIOT; MAZITSCHEK RALPH; TANG WEIPING; SCHREIBER STUART L; HARVARD COLLEGE; DANA FARBER CANCER INST INC
摘要:In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.