CAS: 185331-69-5; 4-Bromo-3-Fluoronitrobenzene

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CAS号1072-85-1 1-溴-2-氟苯 | CAS号586-78-7 对溴硝基苯 | CAS号1073353-89-5 2-氟-4-硝基苯硼酸频那醇酯 | CAS号188975-47-5 DIMETHYL 2-(2-F...

邻溴氟苯置于硫酸,硝酸体系中,化学反应 0.5H,反应生成3-溴-4-氟硝基苯,1-溴-2-氟-4-硝基苯
参考文献:A Novel Method For The Nitration Of Simple Aromatic Compounds
标题:A Novel Method For The Nitration Of Simple Aromatic Compounds
摘要:Simple Aromatic Compounds Such As Benzene,Alkylbenzenes,Halogenobenzenes,And Some Disubstituted Benzenes Are Nitrated In Excellent Yields With High Regioselectivity Under Mild Conditions Using Zeolite Beta As A Catalyst And A Stoichiometric Quantity Of Nitric Acid And Acetic Anhydride. The Zeolite Can Be Recycled,And The Only Byproduct Is Acetic Acid,Which Can Be Separated Easily From The Nitration Product By Distillation; The Process Is Inexpensive And Represents An Attractive Method For The Clean Synthesis Of A Range Of Nitroaromatic Compounds. For Example,Nitration Of Toluene Gives A Quantitative Yield Of Mononitrotoluenes,Of Which 79% Is 4-Nitrotoluene; Fluorobenzene Gives A Quantitative Yield Of Mononitro Compounds,Of Which 94% Is 4-Nitrofluorobenzene; And 2-Fluorotoluene Gives A 96% Yield Of Mononitro Products,Of Which 90% Is The 5-Nitro Isomer And 10% Is The 4-Nitro Isomer.
Doi:10.1021/jo981557O