CAS: 1517-69-7; (R)-1-Phenylethanol

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甲苄醇乙酸酯置于porcine Pancreatic Lipase Covalently Modified With 3-(2-Carboxymethyl)-1-Butylimidazolium Dihydrophosphate体系中,用 Aq. Phosphate Buffer 用作溶剂,化学反应 5.0H,以98%的收率获得
参考文献:通过功能性离子液体的共价修饰增强猪胰脂肪酶的催化性能
标题:通过功能性离子液体的共价修饰增强猪胰脂肪酶的催化性能
摘要:由不同的阳离子和阴离子组成的各种功能性离子液体(il)用羰基二咪唑活化,然后通过赖氨酸偶联共价连接到猪胰脂肪酶(ppl)上.如在对硝基苯基棕榈酸酯(pnpp)水解和外消旋1-苯乙酸乙酯水解反应中所研究的,催化性能,如活性,热稳定性和对映选择性得到了成功的改善.通过催化和光谱数据研究了催化性能与il修饰之间的相关性,显示出不同程度的催化性能改善.具有离液阳离子和高渗阴离子的ils增强了水解活性(例如,[胆碱] [h 2 Po 4 ]的水解活性提高了4倍以上)]).带有正离子和离液性阴离子的il的修饰有助于脂肪酶的热稳定性和对映选择性(例如,用[hoocbmim] [cl]进行的修饰在60oc时显示12倍的热稳定性,而对映体的选择性比天然酶高7倍).基质辅助激光解吸/电离飞行时间质谱实验表明,Il与脂肪酶蛋白结合.通过荧光光谱和圆二色性光谱确认构象变化.
Doi:10.1021/cs400404F

专利信息

专利号:US-10337033-B2
优先权日:2016-12-30
标 题 :Carbonyl reductase oligomers and their application in synthesis of chiral alcohols
发明人：ZHANG RONGZHEN; XU YAN; LI KUNPENG
权利人:ZHANG RONGZHEN; XU YAN; LI KUNPENG; UNIV JIANGNAN
摘要:Disclosed are methods for the synthesis of chiral alcohols by Sortase A-mediated oxidoreductase oligomers, which relates to the field of biocatalysis. In the present disclosure, oxidoreductase oligomers were used as biocatalysts for chiral alcohol preparation. Compared to wild-type enzymes, the oxidoreductase oligomers significantly improved catalytic activity and thermal stability. The sortase A-mediated oxidoreductase oligomers had 6-8 folds improvement in specific activity over that of the wild-type enzymes. The oligomers displayed a T m value 6-12° C. higher than that of the wild-type, suggesting the sortase A-mediated oxidoreductase oligomers significantly improved thermostability of the enzymes. The oxidoreductase oligomers catalyzed asymmetric transformation to produce (S)-1-phenyl-1,2-ethanediol or (R)-1-phenethyl alcohol within 3-6 hr, with an optical purity of 98%-100% and a yield of 98%-99%.

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:US-6469133-B2
优先权日:1999-12-13
标题 :Process for the preparation of polymers of dimeric cyclic esters
发明人：BAKER GREGORY L; SMITH III MILTON R
权利人:UNIV MICHIGAN STATE
摘要:The present invention provides a process for the direct synthesis of high melting polymers made from dimeric cyclic esters. In particular, the present invention provides a process for synthesis of polylactic acid (PLA) from racemic materials such as racemic lactide and polymandelide from mandelide. The process further provides racemic metal organic ligand catalysts such as racemic salbinap that catalyzes the polymerization of racemic dimeric cyclic ester monomers to a polylactide stereocomplex. Polymandelide and mixed dimeric cyclic esters are also prepared in the presence of low amounts of water.

专利号:US-2009093630-A1
优先权日:2007-09-21
标题:Chiral synthesis of diazepinoquinolines
发明人：MEGATI SREENIVASULU; BHANSALI SHILPA; DEHNHARDT CHRISTOPH; DESHMUKH SUBODH; FUNG PETER; MACEWAN MICHAEL; TINDER ROBERT J
权利人:WYETH CORP
摘要:The present invention relates to improved methods of resolution and recrystallization for synthesizing compounds useful as 5HT 2C agonists or partial agonists, including intermediates thereto.

专利号:US-8168828-B2
优先权日:2007-06-25
标题 :Process for the preparation of pregabalin
发明人：SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; SATYANARAYANA REVU
权利人:SATYANARAYANA REDDY MANNE; THIRUMALAI RAJAN SRINIVASAN; ESWARAIAH SAJJA; SATYANARAYANA REVU; MSN LAB LTD
摘要:The present invention encompasses novel intermediates of pregabalin, namely 3-cyano-5-methyl hexanamide (28) and 3-(amino methyl)-5 methyl hexanamide (29), and processes for their preparation. The invention also encompasses a process for converting the novel pregabalin intermediates into pregabalin, Formula (I): The present invention further provides a cost effective method for the synthesis of (S)-pregabalin, which involves the recovery of mandelic acid and tartaric acid used in the resolution process and recycling them, increasing the yields of the final product formed, which substantially reduced the cost of the production.

专利号:US-5097051-A
优先权日:1989-02-10
标题 :Cyclic triketone compounds and trimethylsilyloxy butadiene compounds and their use in the preparation of daunomycinone derivatives
发明人：SCHEEREN JOHAN W; DEBIE JOANNES F M; DEVOS DIRK
权利人:PHARMACHEMIE BV
摘要:The invention provides novel cyclic triketone compounds of the formulae wherein S is H, alkyl or alkoxy and R* is a group of the formule wherein R<1> is methyl and R2 is an alkyl group containing at least 2 carbon atoms, or R<1> is an alkyl group having 1-4 carbon atoms and R<2> is an aryl group, a hetero aryl group, a -CH2OR min , a -CH2N @@ group, a -CH2SR sec group or a -CH2CH=CH2 group, wherein R min and R sec are alkyl groups having 1-4 carbon atoms. These compounds can be used for preparing daunomycinone and derivatives thereof. Daunomycinone is used for preparing daunomycin and adriamycin. By introducing chirality at C-1 of ring A in the preparation of said novel compounds by using a novel diene of formula (1) in a Diels-Alder reaction for said preparation, the chirality of C-3 is established in the subsequent reaction with LiC IDENTICAL CSi(CH3)3 in the synthesis of daunomycinone and derivatives thereof. This last reaction leads to the desired compound wherein OH at C-3 and OR at C-1 are in the cis-position with respect to each other.