CAS: 150915-40-5; (S)-2-(Butylsulfonamido)-3-(4-(4-(Piperidin-4-yl)Butoxy)Phenyl)Propanoic Acid Hydrochloride Hydrate

N-N-Butylsulfonyl-O-(4-(Pyridin-4-yl)But-3-Yn-1-yl)-L-Tyrosine置于5%-Palladium/activated Carbon,氢气,溶剂黄146,盐酸体系中,用 醋酸异丙酯,水 用作溶剂,化学反应 10.0H,以25.9 G的收率获得盐酸替罗非班
参考文献:盐酸替罗非班的制备
标题:盐酸替罗非班的制备
摘要:本发明涉及一条制备盐酸替罗非班的方法.该方法以n‑正丁基磺酰基‑l‑络氨酸酯和3‑丁炔‑1‑醇为起始物料,通过缩合反应制备得到o‑3‑炔丁基‑n‑正丁基磺酰基‑l‑络氨酸酯,然后再和4‑卤代吡啶通过sonogashira偶联反应制备得到n‑正丁基磺酰基‑o‑(4‑(吡啶‑4‑基)丁‑3‑炔‑1‑基)‑l‑络氨酸酯,后者再通过氢化反应,盐酸成盐完成盐酸替罗非班的制备.

专利信息

专利号:US-9744252-B2
优先权日:2011-08-17
标 题:Compounds for binding to the platelet specific glycoprotein IIb/IIIa and their use for imaging of thrombi
发明人：BERGER MARKUS; KRUGER MARTIN; LOHRKE JESSICA; REINHARDT MICHAEL; SIEBENEICHER HOLGER
权利人:PIRAMAL IMAGING SA
摘要:The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein IIb/IIIa antagonists for imaging of thrombi.

专利号:US-8926945-B2
优先权日:2005-10-07
标题:Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
发明人：PORT MARC; COROT CLAIRE; GAUTHERET THIERRY
权利人:PORT MARC; COROT CLAIRE; GAUTHERET THIERRY; GUERBET SA
摘要:The invention concerns compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium. The invention also concerns methods for obtaining said compounds, screening methods capable of selecting such compounds for chemical synthesis thereof and their diagnostic applications, in particular in PET, PET/IRM, PET CT imaging.

专利号:US-2013030282-A1
优先权日:2011-07-18
标题:Synthesis and characterization of near ir fluorescent magnetic and non-magnetic albumin nanoparticles for biomedical applications
发明人：MARGEL SHLOMO; COHEN SARIT; SALKMON ENAV COREM; PELLACH MICHAL
权利人:UNIV BAR ILAN; MARGEL SHLOMO; COHEN SARIT; SALKMON ENAV COREM; PELLACH MICHAL
摘要:The present invention discloses Near Infrared (NIR) fluorescent albumin nanoparticles having a structure selected from a core structure or a core-shell structure. Also disclosed are a process of preparing these NIR fluorescent albumin nanoparticles, and a method of in vivo detection of pathologies, in particular cancer pathology, by using administering these NIR fluorescent albumin nanoparticles to a patient.

专利号:US-2022411407-A1
优先权日:2019-11-15
标题:Aryl aminopyrimidines as dual mertk and tyro3 inhibitors and methods thereof
发明人：WANG XIAODONG; ZHOU YUBAI; DING RANSHENG; KONG DEYU; FRYE STEPHEN
权利人:UNIV NORTH CAROLINA CHAPEL HILL
摘要:Aminopyrimidine containing compounds that inhibit both Mer tyrosine kinase (MerTK) activity and Tyro3 kinase activity are disclosed herein. Additionally disclosed are methods of synthesis and use of the aminopyrimidine containing compounds as anti-cancer agents, immunostimulatory and immunomodulatory agents, anti-platelet agents, anti-infective agents, and as adjunctive agents.

专利号:CN-1740158-A
优先权日:2005-09-26
标题:Synthesis process of Tilofiban hydrochloride intermediate