📜1-氯戊烷置于sodium,Petroleum Ether体系中,化学反应生成己基苯 参考文献:Morton; Fallwell,Journal Of The American Chemical Society,1937,Vol. 59,P. 2388 标题:Morton; Fallwell,Journal Of The American Chemical Society,1937,Vol. 59,P. 2388
专利信息
专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-11306041-B2 优先权日:2017-03-30 标 题:Catalytic synthesis of super linear alkenyl arenes using rhodium catalysts 发明人:SCHINSKI WILLIAM; GOLDMAN ALAN; GUNNOE THOMAS B; WEBSTER-GARDINER MICHAEL S; SCHWARTZ NICHOLE 权利人:UNIV VIRGINIA PATENT FOUNDATION 摘要:Catalytic methods for synthesis of super linear alkenyl arenes and alkyl arenes are provided. The methods are capable of synthesizing super linear alkyl and alkenyl arenes from simple arene and olefin starting materials and with high selectivity for linear coupling. Methods are also provided for making a 2,6-dimethylnapthalene (DMN) or 2,6-methylethylnapthalene (MEN).
专利号:US-2014135497-A1 优先权日:2012-11-13 标题 :Synthesis of 2,4-dichloro-5-trifluoromethyl-pyrimidine 发明人:LIU LI; AKALAY DENIZ; DONG WEITONG; FENG JIANQING; HEMP CHRISTIAN WOLFGANG; LU JUN; XIE LE; YANG JINSONG 权利人:LIU LI; AKALAY DENIZ; DONG WEITONG; FENG JIANQING; HEMP CHRISTIAN WOLFGANG; LU JUN; XIE LE; YANG JINSONG; BOEHRINGER INGELHEIM INT 摘要:This invention relates to a novel method for the synthesis of 2,4-dichloro-5-trifluoromethyl-pyrimidine useful as intermediate in the manufacture of pharmaceutically active ingredients.
专利号:US-7632975-B2 优先权日:2004-12-22 标 题:Process for the synthesis of arylfluorenes and analogs thereof 发明人:HEIDENHAIN SOPHIE 权利人:CDT OXFORD LTD 摘要:A process is provided for the synthesis of a compound of formula (I): n nwherein:n M=0 or 1; N and p are 0 or 1 to 4; X is a single bond, O, S or NH; And R 1 -R 4 are as defined in claim 1.
专利号:US-9676726-B2 优先权日:2013-12-23 标题:Process for the regioselective synthesis of pyrazoles 发明人:MEAZZA GIOVANNI; SILLANI LAURA; MEREGHETTI PIERANGELO; FORGIA DANIELE 权利人:ISAGRO SPA 摘要:A process is described for the synthesis of pyrazoles having general formula (I) n nwhich comprises the steps of mixing a compound having general formula (II)n n nand a 1,2-disubstituted hydrazine having general formula (III)n n nto form a reaction intermediate having general formula (IV)n n nand the reaction mixture obtained in step i), in an acid environment, cyclizes to form a pyrazole having general formula (I), according to reaction scheme 1
专利号:US-4189583-A 优先权日:1978-04-26 标题 :Synthesis of 4A-aryl-decahydroisoquinolines 发明人:GLESS RICHARD D; RAPOPORT HENRY; WELLER DWIGHT D 权利人:U S OF AMERICA HEW SECRETARY 摘要:This invention relates to a process for the production of 4a-aryldecahydroisoquinolines where the aryl group is selected as 3-methoxy phenyl. These compounds are morphine analogs and show utility similar to the known morphine, codeine, and thebaine. In this process particular novelty is asserted for the production of a nipecotic ester ethyl 4-(3'-methoxyphenyl)-1-methyl piperidine-3-carboxylate. Furthermore, novelty is asserted for the step of conversion of the nipecotates through cyclization to cis- or trans-tert-butyl 1,6-dioxo-4a-(3'-methoxyphenyl)-2-methyldecahydroisoquinoline-7-carboxylate, which may also be easily converted to the keto amide, trans-1,6-dioxo-4a-(3'-methoxyphenyl)-2-methyldecahydroisoquinoline.
[参考文献]: Hiroshi Kobayashi, Et Al. Faster Axial Band Dispersion In A Monolithic Silica Column Than In A Particle-Packed Column. J Chromatogr A. 2006 Mar 17;1109(1):2-9. [参考文献]: Yi Min, Et Al. 1.9 μm Superficially Porous Packing Material With Radially Oriented Pores And Tailored Pore Size For Ultra-Fast Separation Of Small Molecules And Biomolecules. J Chromatogr A. 2014 Aug 22:1356:148-56.
合成参考文献
摘要:Wicha, J., Science of Synthesis, (2009) 48, 108. 摘要:Zysman-Colman, E., Science of Synthesis, (2010) 45, 178. 摘要:Eilbracht, P., Science of Synthesis, (2009) 48, 405. 摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2018) 4, 145. 摘要:Wolf, C., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 875.