CAS: 99479-66-0; 2,6-Dichloro-4-(Trifluoromethoxy)Aniline

上下游产品

4-(trifluoromethoxy)aniline N-(2,6-dichloro-4-(trifluoromethoxy)phenyl)propionamide

📜对三氟甲氧基苯胺置于n-氯代丁二酰亚胺体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 6.0H,以93%的收率获得产物2,6-二氯-4-(三氟甲氧基)苯胺
参考文献: Oga Inhibitor Compounds[fr] Composés Inhibiteurs D'Oga
标题: Oga Inhibitor Compounds[fr] Composés Inhibiteurs D'Oga
摘要:本发明涉及o-Glcnac水解酶(oga)抑制剂.该发明还涉及包含这类化合物的药物组合物,制备这类化合物和组合物的方法,以及利用这类化合物和组合物预防和治疗抑制oga有益的疾病的用途,例如tau病变,特别是阿尔茨海默病或进行性上行性麻痹;以及伴有tau病理的神经退行性疾病,特别是由c9Orf72突变引起的肌萎缩侧索硬化或额颞叶痴呆.

专利信息

专利号:US-2008176865-A1
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:US-7968584-B2
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER; PFIZER PROD INC
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:WO-2006134459-A1
优先权日:2005-06-15
标题 :Substituted arylpyrazoles
发明人：CRITCHER DOUGLAS JAMES; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD; CRITCHER DOUGLAS JAMES; KYNE GRAHAM MICHAEL
摘要:This invention relates to a range of C4 substituted aryl pyrazoles of Formula (I) including those 1-arylpyrazoles in which the 4-position is substituted with an acyclic substituent, a cycloalkyl ring structure or heterocyclic ring structure and which compounds are optionally further substituted at the position a to the pyrazole ring, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:RU-2035452-C1
优先权日:1985-12-20
标 题 :Method of n-phenylpyrazole synthesis

专利号:US-7645786-B2
优先权日:2005-06-15
标题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:US-7803832-B2
优先权日:2004-03-18
标题 :N-(1-arylpyrazol-4L)sulfonamides and their use as parasiticides
发明人：CRITCHER DOUGLAS JAMES; WALSHE NIGEL DEREK ARTHUR; LAURET CHRISTELLE
权利人:PFIZER; PFIZER PROD INC
摘要:The invention relates to a sulfonamide compound of formula (I) or a pharmaceutically, veterinarily or agriculturally acceptable salt or solvate thereof, where the groups R 1 -R 5 are described in the description, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.