CAS: 88043-21-4; Boc-Trans-4-Tosyloxy-L-Proline Methyl Ester

上下游产品

CAS号74844-91-0 N-B°C-反式-4-羟基-L... | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号40216-83-9 L-羟脯氨酸甲酯盐酸盐 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号51-35-4 L-羟脯氨酸 | CAS号487048-28-2 顺式-N-b°C-4-氰基-l... | CAS号194163-91-2 反式-N-B°C-4-氰基-L... | CAS号121148-01-4 (2S,4S)-1-B°C-4... | CAS号203866-16-4 N-叔丁氧羰基-顺式-4-氟-...

📜L-羟基脯氨酸置于氯化亚砜,三乙胺体系中,用 甲醇,二氯甲烷,乙腈 作为反应溶剂,化学反应 35.0H,反应生成 N-Boc-反式-4-对甲苯磺酰氧基-L-脯氨酸甲酯
参考文献:通过桥三环双脯氨酸类似物的n封端,在线性肽链中有效的α-螺旋诱导
标题:通过桥三环双脯氨酸类似物的n封端,在线性肽链中有效的α-螺旋诱导
摘要:二级结构诱导:合成的三环氨基酸prom-5是通过将亚乙烯基桥立体选择性地引入到二脯氨酸单元中而正式形成的,它是在线性肽链中成核α-螺旋形成的强大支架.在开发新的蛋白质组蛋白来调节蛋白质相互作用中,可以利用这一点.
DOI:10.1002/anie.201302014

专利信息

专利号:US-9895454-B2
优先权日:2014-07-03
标题:Metal oxide catalyzed radiofluorination
发明人：SERGEEV MAXIM; MORGIA FEDERICA; VAN DAM ROBERT MICHAEL; LAZARI MARK
权利人:UNIV CALIFORNIA
摘要:Inter alia, the first titania-catalyzed [ 18 F]-radiofluorination in highly aqueous medium is provided. In embodiments, the method utilizes titanium dioxide, 1:1 acetonitrile-thexyl alcohol solvent mixture and tetrabutylammonium bicarbonate as a base. Radiolabeling may be directly performed with aqueous [ 18 F]fluoride without the need for drying/azeotroping step, which reduces radiosynthesis time while keeping high fluoride conversion. The general applicability of the synthetic strategy to the synthesis of the wide range of PET probes from tosylated precursors is demonstrated.