CAS: 82477-67-6; 3-Chloro-5-Methoxybenzoic Acid

该化合物是一种芳烃式的碳酸,其特点是在苯化酸框架中存在一个氯组和一个甲氧组,该氯组位于相对于碳酸的元位置(3个位置),而甲氧组位于准位置(5个位置),该化合物一般是白色至非白色固体的,在有机溶剂中溶解,由于水溶性芳香结构,水溶性有限.该化合物具有酸性,因为氨基酸功能组可以将质子捐献在溶液中.该物质的存在可影响其再活动,使其在各种化学合成化学合成和应用(包括药品和农用化学品)中有用.此外,该化合物可能展示出生物活动,可在医药化学环境中加以探讨.在处理和储存时,应参考安全数据,如所有化学物质一样,用于处理和储存.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号124-38-9 二氧化碳 | CAS号33719-74-3 3,5-二氯苯甲醚 | CAS号51-36-5 3,5-二氯苯甲酸 | CAS号124-41-4 甲醇钠 | CAS号67-56-1 甲醇 | CAS号13362-34-0 3-methyl-1,4-be... | CAS号53984-36-4 3-氯-5-羟基苯甲酸 | CAS号82477-68-7 (3-氯-5-甲氧基苯基)甲醇 | CAS号89106-39-8 1-(3-chloro-5-m... | CAS号89106-53-6 Benzoyl chlorid... | CAS号98406-04-3 3-氯-5-羟基苯甲酸甲酯

合成工艺路线路线简述

  • 51-36-5 = 82477-67-6
    反应条件:1.1 Solvents: Hexamethylphosphoramide; 2 D,120 °C
    标题:Discovery And Optimization Of Crth2 And Dp Dual Antagonists
    作者:Liu,Jiwen; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2009 卷标:19(22) 页码:6419-6423]

    2845-89-8 = 82477-67-6
    反应条件:1.1 Reagents: Bis(Pinacolato)Diborane Catalysts: Bis[(1,2,5,6-η)-1,5-Cyclooctadiene]Di-μ-Methoxydiiridium,4,4′-Bis(1,1-Dimethylethyl)-2,2′-Bipyridine Solvents: Dimethoxymethane; 24 H,80 °C1.2 Reagents: Cesium Fluoride Catalysts: [1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylidene]Iodocop... Solvents: Dimethoxymethane; 24 H,120 °C
    标题:Formal C-H Carboxylation Of Unactivated Arenes
    作者:Gevorgyan,Ashot; Et Al
    参考文献:Chemistry - A European Journal 日期:2020 卷标:26(27) 页码:6064-6069]

    51-36-5 = 82477-67-6
    反应条件:1.1 Reagents: Sodium Methoxide Solvents: Hexamethylphosphoramide
    标题:Syntheses Of Phenolic Metabolites Of An Antifungal Imidazole Derivative (Cloconazole Hydrochloride)
    作者:Takahashi,Kimio; Et Al
    参考文献:Heterocycles 日期:1985 卷标:23(6) 页码:1483-91]

    82477-63-2 = 82477-67-6
    反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid2.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1)
    标题:Reaction Of Some 1,4-Benzoquinone Monooximes With Methanolic Hydrogen Chloride
    作者:Sargent,Melvyn V.
    参考文献:Journal Of The Chemical Society 日期:1982 卷标:(4) 页码:1095-8]

    99-34-3 + 865-34-9 = 82477-67-6
    反应条件:1.1 Solvents: Hexamethylphosphoramide; 18 H,Rt; 6 H,80 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Cooled2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl Acetate3.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water; 5 °C; 30 Min,0 °C3.2 Reagents: Hydrochloric Acid,Cuprous Chloride Solvents: Water; < 10 °C; 1 H,Rt; 30 Min,80 °C
    标题:The Role Of Substitution In The Apex Position Of The Bent-Core On Mesomorphic Properties Of New Series Of Liquid Crystalline Materials
    作者:Skopalova,Helena; Et Al
    参考文献:Crystals 日期:2020 卷标:10(9)]

    51-36-5 = 82477-67-6
    反应条件:1.1 Solvents: Methanol,Hexamethylphosphoramide; 15 H,120 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified
    标题:Discovery Of Highly Potent V600E-B-Raf Kinase Inhibitors: Molecular Modeling Study
    作者:Tarazi,Hamadeh; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2019 卷标:27(4) 页码:655-663]

    74165-74-5 = 82477-67-6
    反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water; 5 °C; 30 Min,0 °C1.2 Reagents: Hydrochloric Acid,Cuprous Chloride Solvents: Water; < 10 °C; 1 H,Rt; 30 Min,80 °C
    标题:The Role Of Substitution In The Apex Position Of The Bent-Core On Mesomorphic Properties Of New Series Of Liquid Crystalline Materials
    作者:Skopalova,Helena; Et Al
    参考文献:Crystals 日期:2020 卷标:10(9)]

    82477-65-4 = 82477-67-6
    反应条件:1.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1)
    标题:Reaction Of Some 1,4-Benzoquinone Monooximes With Methanolic Hydrogen Chloride
    作者:Sargent,Melvyn V.
    参考文献:Journal Of The Chemical Society 日期:1982 卷标:(4) 页码:1095-8]

    82477-66-5 = 82477-67-6
    反应条件:1.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1)
    标题:Reaction Of Some 1,4-Benzoquinone Monooximes With Methanolic Hydrogen Chloride
    作者:Sargent,Melvyn V.
    参考文献:Journal Of The Chemical Society 日期:1982 卷标:(4) 页码:1095-8]

    78238-12-7 = 82477-67-6
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl Acetate2.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water; 5 °C; 30 Min,0 °C2.2 Reagents: Hydrochloric Acid,Cuprous Chloride Solvents: Water; < 10 °C; 1 H,Rt; 30 Min,80 °C
    标题:The Role Of Substitution In The Apex Position Of The Bent-Core On Mesomorphic Properties Of New Series Of Liquid Crystalline Materials
    作者:Skopalova,Helena; Et Al
    参考文献:Crystals 日期:2020 卷标:10(9)]

    82477-62-1 = 82477-67-6
    反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid2.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1)
    标题:Reaction Of Some 1,4-Benzoquinone Monooximes With Methanolic Hydrogen Chloride
    作者:Sargent,Melvyn V.
    参考文献:Journal Of The Chemical Society 日期:1982 卷标:(4) 页码:1095-8
📜3,5-二氯苯甲酸置于sodium Methylate,三(二甲胺基)膦,盐酸体系中,用 水 作为反应溶剂,化学反应 48.0H,反应生成 3-氯-5-甲氧基苯甲酸
参考文献:Substituted Diphenylethers,-Amines,-Sulfides And-Methanes For The Treatment Of Respiratory Disease
标题:Substituted Diphenylethers,-Amines,-Sulfides And-Methanes For The Treatment Of Respiratory Disease
摘要:这项发明涉及替代二苯醚,-胺,-硫化物和-甲烷作为治疗呼吸系统疾病的有用药物化合物,包含它们的药物组合物,以及它们的制备方法.

海关参考信息

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


参考文献:10.1007/s00044-017-1923-9
摘要:Park B, El-Gamal MI, Lee W, Shin J, Yoo KH, Lee K, Oh C. Synthesis and inhibitory effects of triarylpyrazoles on LPS-induced NO and PGE2 productions in RAW 264.7 macrophages. Medicinal Chemistry Research. 2017 May 29;26(9):2161–71. doi: 10.1007/s00044-017-1923-9.
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知