专利号:EP-1491540-B1 优先权日:2001-03-30 标题 :Intermediates useful for the synthesis of pyridazinone aldose reductase inhibitors
专利号:US-7473786-B1 优先权日:2003-12-05 标题:Methods and systems for preparing fused heterocyclic compounds using copper(I) catalysts 发明人:VENKATARAMAN DHANDAPANI; BATES CRAIG G; SAEJUENG PRANORM 权利人:UNIV MASSACHUSETTS 摘要:A copper(I)-catalyzed procedure for the synthesis of benzo[b]heterocycles. This protocol can be used to synthesize a variety of 2-arylbenzo[b]furans and indoles in good to excellent yields. This method can tolerate a variety of functional groups, does not require the use of expensive additives and is palladium-free.
专利号:ES-2274369-T3 优先权日:2001-03-30 标 题:USEFUL INTERMEDIATES FOR SYNTHESIS OF PIRIDAZINONAS INHIBIDORAS OF ALDOSA REDUCTASA.
专利号:US-9067934-B2 优先权日:2011-03-31 标题 :Bicyclic pyridinones 发明人:PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; GREEN MICHAEL ERIC; MULLINS PATRICK BRADLEY; STIFF CORY MICHAEL; TRAN TUAN PHONG; NAVARATNAM THAYALAN 权利人:PFIZER 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:CN-115197182-A 优先权日:2022-07-01 标 题:A kind of synthesis technique of halogenated dibenzofuran derivative
专利号:US-11286268-B1 优先权日:2019-07-02 标题:EIF4E-inhibiting compounds and methods 发明人:SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE 权利人:EFFECTOR THERAPEUTICS INC 摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.
参考标题:Construction Of 2-Substituted-3-Functionalized Benzofurans Via Intramolecular Heck Coupling: Application To Enantioselective Total Synthesis Of Daphnodorin B 作者:Hu Yuan,Kai-Jian Bi,Bo Li,Rong-Cai Yue,Ji Ye,Yun-Heng Shen,Lei Shan,Hui-Zi Jin,Qing-Yan Sun,Wei-Dong Zhang |发布日期:2013.9.20 摘要:A Novel Approach Was Developed For The Synthesis Of 2-Substituted-3-Functionalized Benzofurans, Using An Intramolecular Heck Reaction Which Was Further Applied In The First Enantioselective Total Synthesis Of Daphnodorin B.
合成参考文献
摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 68. 摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 63. 摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, . 摘要:Cheng, B.; Wang, T., Science of Synthesis Knowledge Updates, (2020) 3, 191.