CAS: 698394-73-9; Vercirnon

上下游产品

4-Tert-Butyl-N-[4-Chloro-2-(Pyridine-4-Carbonyl)-Phenyl]-Benzenesulfonamide 698394-72-8
(2-氨基-5-氯苯基)-4-吡啶基甲酮 (2-Amino-5-Chlorophenyl)(Pyridin-4-yl)Methanone 105192-42-5

📜4-Tert-Butyl-N-[4-Chloro-2-(Pyridine-4-Carbonyl)-Phenyl]-Benzenesulfonamide置于间氯过氧苯甲酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 16.0H,以35%的收率获得产物维塞诺
参考文献:靶向 Ccr9 细胞内结合位点的化学生物学工具箱:荧光配体,新药先导物和 Protac
标题:靶向 Ccr9 细胞内结合位点的化学生物学工具箱:荧光配体,新药先导物和 Protac
摘要:基于细胞内 Ccr9 拮抗剂 Vercirnon,我们开发了第一个基于小分子的荧光配体,靶向 Gpcr 的细胞内变构结合位点 (Iabs).该工具能够通过 Nanobret,荧光显微镜进行结合研究,并发现具有更高亲和力的新型细胞内 Ccr9 拮抗剂.为了诱导 Ccr9 降解,我们开发了第一个针对 Gpcr 的 Iabs 的 Protac.
DOI:10.1002/anie.202116782

专利信息

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-10308615-B2
优先权日:2015-05-29
标 题:Heterocyclic compounds as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; CONDON JEFFREY SCOTT; FLICK ANDREW CHRISTOPHER; GOPALSAMY ARIAMALA; KIRINCICH STEVEN J; MATHIAS JOHN PAUL; STROBACH JOSEPH WALTER; XIANG JASON SHAOYUN; XING LI HUANG; WANG XIAOLUN
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2018230127-A1
优先权日:2015-08-13
标题 :Bicyclic-Fused Heteroaryl Or Aryl Compounds
发明人：ANDERSON DAVID RANDOLPH; CURRAN KEVIN JOSEPH; GAVRIN LORI KRIM; GOLDBERG JOEL ADAM; LEE ARTHUR; LOWE MICHAEL DENNIS; PATNY AKSHAY; PIERCE BETSY SUSAN; SAIAH EDDINE; TRZUPEK JOHN DAVID
权利人:PFIZER
摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds of Formula (Ia) are disclosed which are inhibitors of Interleukin-1 receptor associated kinase (IRAK4). Methods of treatment, methods of synthesis, and intermediates are also disclosed as defined in the specification.

专利号:US-10316018-B2
优先权日:2015-08-27
标题 :Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators
发明人：LEE KATHERINE LIN; ALLAIS CHRISTOPHE PHILIPPE; DEHNHARDT CHRISTOPH MARTIN; GAVRIN LORI KRIM; HAN SEUNGIL; HEPWORTH DAVID; LEE ARTHUR; LOVERING FRANK ELDRIDGE; MATHIAS JOHN PAUL; OWEN DAFYDD RHYS; PAPAIOANNOU NIKOLAOS; SAIAH EDDINE; STROHBACH JOSEPH WALTER; TRZUPEK JOHN DAVID; WRIGHT STEPHEN WAYNE; ZAPF CHRISTOPH WOLFGANG
权利人:PFIZER
摘要:Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia, n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:CN-118955233-B
优先权日:2024-07-27
标题 :Synthesis method of monosubstituted bicyclo [1.1.1] pentane (BCP)

专利号:CN-118955233-A
优先权日:2024-07-27
标 题:Synthesis method of monosubstituted bicyclo [1.1.1] pentane (BCP)