CAS: 623-73-4; Ethyl Diazoacetate

上下游产品

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重氮基乙酰乙酸乙酯置于potassium Hydroxide体系中,用 乙醚,水 作为反应溶剂,化学反应生成 重氮乙酸乙酯
参考文献:以重氮化合物为自由基前体光催化合成茚满酮,吡喃酮和吡啶酮衍生物
标题:以重氮化合物为自由基前体光催化合成茚满酮,吡喃酮和吡啶酮衍生物
摘要:我们在此公开了重氮烷烃的光催化自由基级联环化,用于重要碳环和杂环的发散合成.在最佳反应条件下,可以以中等至非常好的收率得到各种茚满酮,吡喃酮和吡啶酮衍生物.机理实验支持重氮烷通过质子耦合电子转移过程形成以碳为中心的自由基.使用连续流技术的放大反应和所形成的杂环的有用下游应用进一步使该策略具有吸引力和价值.
DOI:10.1021/acs.Orglett.3C04331

专利信息

专利号:EP-2644590-A1
优先权日:2012-03-30
标 题:Synthesis of 2-(3,4-difluorophenyl)cyclopropanamine derivatives and salts
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

专利号:US-6025492-A
优先权日:1996-08-30
标 题 :Synthesis of a hydrazone β-keto ester by the reaction with a diazo ester
发明人：SHAH AJIT S; CLARK JERRY D; MA YINONG; PETERSON JAMES C; PATELIS LEFTERIS
权利人:MONSANTO CO
摘要:The present invention relates to the synthesis of a hydrazone β-keto ester by the reaction of an alkyl diazoester with a hydrazone aldehyde in the presence of a Lewis acid In a preferred embodiment, the hydrazone β-keto ester is then converted into a pyridazinone compound by the reaction with an alkyl acid chloride in the presence of a base, followed by acidification. A process for the production of a hydrazone aldehyde, which comprises contacting a hydrazine and glyoxal, is also described.

专利号:US-6258960-B1
优先权日:2000-03-17
标题:Catalytic asymmetric synthesis of chiral aziridines
发明人：ANTILLA JON; WULFF WILLIAM D
权利人:ARCH DEV CORP
摘要:The present invention relates to the synthesis of chiral cis-aziridines (IIIa and IIIb) by reacting an imine (I) with a diazo compound (II) in the presence of a chiral vaulted biary-Lewis Acid complex as shown below:

专利号:US-4284582-A
优先权日:1978-04-28
标 题 :Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides
发明人：KAYE ALBERT E; TUCKER ALAN C
权利人:ICI LTD
摘要:Compounds of formula: wherein both groups X are chlorine, bromine or trifluoromethyl, or one X is chlorine or bromine and the other is trifluoromethyl, and Y is -CN or -COOR in which R is an alkyl group, are obtained by (A) reacting a compound of the formula: wherein X1 is chlorine or bromine, with a compound of the formula: X2C=CH-CH=C(CH3)2 in the presence of metallic copper or at least one copper salt and a base, or (B) reacting a compound of the formula: Y-CH2-CN with a compound of the formula: X2C=CH-CH=C(CH3)2 and chlorine or bromine, in the presence of at least one reducible copper salt and a base, or (C) reacting a compound of formula: X-CH2-CN with a compound of the formula: wherein X1 is chlorine or bromine, in the presence of at least one copper salt. The compounds are intermediates in the synthesis of pyrethroid insecticides.

专利号:WO-0056708-A1
优先权日:1999-03-19
标题 :Catalytic asymmetric synthesis of chiral aziridines
发明人：WULFF WILLIAM D; ANTILLA JON
权利人:ARCH DEV CORP
摘要:The present invention relates to the synthesis of chiral cis-aziridines (IIIa and IIIb) by reacting an imine (I) with a diazo compound (II) in the presence of a chiral vaulted biaryl-Lewis Acid complex as shown.

专利号:US-3699146-A
优先权日:1970-03-31
标题:Synthesis of methyl malvalate and methyl 5,6-methano-5-undecenoate
发明人：GENSLER WALTER J
权利人:US AGRICULTURE
摘要:This invention relates to the preparation of methyl malvalate, methyl 5,6-methano-5-undecenoate and the preparation of some new intermediates. Malvalic acid, the major cyclopropene component in cottonseed oil, has been synthesized. When 1-chloro-7-hexadecyne reacts with diazoacetic ester in the presence of copper bronze, the ester of 1-chloro-7,8-carboxymethano-7-hexadecene is formed. Treating the corresponding acid chloride with zinc chloride causes loss of carbon monoxide. Either sodium borohydride or lithium aluminum hydride reduces the resulting cyclopropenium compound to 1-chloro-7,8-methano-7-hexadecene. Replacing the chloro group with cyano yields malvalonitrile, which can be converted to methyl malvalate. An analogous sequence of steps has been applied to 1-chloro-4-decyne to produce methyl 5,6-methano5-undecenoate. An alternate synthesis of methyl malvalate starts by using 1-chloro-7-hexadecyne as the precursor for methyl 8heptadecynoate. This acetylenic ester is converted to 8,9carboxymethano-8-heptadecenoic acid, the diacid chloride of which decarbonylates selectively in the presence of metallic chlorides to form the cyclopropenium-acid chloride. After esterification the resulting cyclopropenium-ester is reduced with borohydride to methyl malvalate.