📜3-甲基苯胺置于ammonium Hydroxide体系中,用 甲醇,丙酮 作为反应溶剂,化学反应生成 间甲苯基-2-硫脲 参考文献:Synthesis And Antitumor Evaluation Of 5-(Benzo[d][1,3]Dioxol-5-Ylmethyl)-4-(Tert-Butyl)-N-Arylthiazol-2-Amines 标题:Synthesis And Antitumor Evaluation Of 5-(Benzo[d][1,3]Dioxol-5-Ylmethyl)-4-(Tert-Butyl)-N-Arylthiazol-2-Amines 摘要:设计靶向化合物作为抗肿瘤药物的策略. DOI:10.1039/c6Md00234J
专利号:CN-111808044-A 优先权日:2020-06-30 标 题 :Novel green synthesis method for efficiently synthesizing aminothiazole derivative through carbene insertion/cyclization reaction under catalysis of transition metal
专利号:CN-111808044-B 优先权日:2020-06-30 标 题 :Green synthesis method for efficiently synthesizing aminothiazole derivative through carbene insertion/cyclization reaction under catalysis of transition metal
参考标题:Synthesis Of 2-Aminothiazoles Via Rhodium-Catalyzed Carbenoid Insertion/annulation Of Sulfoxonium Ylides With Thioureas 作者:Yuncan Chen,Shan Lv,Ruizhi Lai,Yingying Xu,Xin Huang,Jianglian Li,Guanghui Lv,Yong Wu |发布日期:2021.8 摘要:Sulfoxonium Ylides As Carbene Precursors Couple Smoothly With Thioureas In The Presence Of 5 Mol% Of Rhodium(II) Acetate Dimmer Via Carbenoid Insertion To Afford The Corresponding 2-Aminothiazoles With High Chemoselectivity, Providing A Facile And Efficient Approach To Access A Variety Of 2-Aminothiazole Derivatives With Good Functional Groups Tolerance.
合成参考文献
摘要:Aggarwal, P.; Bebbington, M. W. P., Science of Synthesis Knowledge Updates, (2012) 2, 474. 摘要:National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review., 5(45), 1953