CAS: 59468-44-9; 8-Chloro-6-(2-Fluorophenyl)-1-Methyl-4H-Imidazo[1,5-A][1,4]Benzodiazepine-3-Carboxylic Acid
该化合物是一种化学化合物,其特点是其结构复杂,包括一个与imidazole环结合的苯并二氮并二氮并二氮基核心体,该化合物具有8位置的氯替代成分和6位置的氟联苯组,有助于其独特的化学特性和潜在的生物活动;3位置上存在一个碳oxylic酸功能组,可增强其在极溶剂中的溶性,并可能影响其药用相互作用;该化合物对医药化学具有兴趣,特别是其有可能用于针对各种...
- 英文名称8-Chloro-6-(2-Fluorophenyl)-1-Methyl-4H-Imidazo[1,5-A][1,4]Benzodiazepine-3-Carboxylic Acid
- 中文名称8-氯-6-(2-氟苯基)-1-甲基-4H-咪唑并[1,5-a][1,4]苯并二氮杂卓-3-羧酸
- IUPAC名称8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid
- 其它别名8-chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid; 8-CHLOOR-6-(2-FLUORFENYL)-1-METHYL-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBONZUUR
- CAS编号59468-44-9
- EINECS号:261-777-1
- FDA UNII编号:P5URY5OSB9
- 分子式:C19H13ClFN3O2分子量:369.783
- 产品CID: 1571360
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
上下游产品
8-Chloro-6-(2-Fluoro-Phenyl)-1-Methyl-4H-Benzo[f]Imidazo[1,5-A][1,4]Diazepine-3-Carboxylic Acid Methyl Ester 59468-42-7合成工艺路线路线简述
📜8-Chloro-6-(2-Fluorophenyl)-1-Methyl-4H-Imidazo[1,5-A][1,4]Benzodiazepine-5-Oxide-3-Carboxylic Acid置于anhydrous Phosphorus Trichloride体系中,用 Sodium Hydroxide,二氯甲烷 作为反应溶剂,化学反应生成 8-氯-6-(2-氟苯基)-1-甲基-4H-咪唑并[1,5-A][1,4]苯并二氮杂卓-3-羧酸
参考文献:Intermediates For The Production Of Imidazobenzodiazepines
标题:Intermediates For The Production Of Imidazobenzodiazepines
摘要:介绍了公式##str1##的新型中间体,其中x和y分别为氢,卤素或三氟甲基,R.Sub.1为氢或低碳基.还披露了一种导致这些中间体的过程以及它们转化为咪唑苯二氮杂苯并二氮杂苯的化合物的方法.
海关参考信息
- 2902300000-甲苯
2903919090-氯苯
2905110000-甲醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6512114-B1
优先权日:1999-06-30
标 题 :Process for the preparation of Midazolam
发明人：DHAON MADHUP K; ESSER GRANT L; DAVIS DEBORAH A; BHATIA ASHOK V
权利人:ABBOTT LAB
摘要:The present invention provides a process for the synthesis of Midazolam Ifrom a compound of formula II,using thermodynamic, basic workup conditions. Additional steps to isolate the pure bulk product follow.
专利号:US-8557981-B2
优先权日:2010-05-04
标题:Process for the synthesis of 4H-imidazo [1,5-a] [1,4] benzodiazepines, in particular midazolam and salts thereof
发明人：CASTELLIN ANDREA; MAGGINI MICHELE; DONNOLA PAOLA
权利人:CASTELLIN ANDREA; MAGGINI MICHELE; DONNOLA PAOLA; ITALIANA SINT SPA
摘要:The present invention refers to a process for the preparation of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular Midazolam, through an efficient and selective decarboxylation reaction of the derivative compound of the 5-aminomethyl-1-phenyl-1H-imidazole-4-carboxylic acid of formula (II) n navoiding the formation of the 6H-imidazo[1,5-a][1,4]benzodiazepines by-products and the ensuing process for the isomerization of a 4H-imidazo[1,5-a][1,4]benzodiazepine product.
专利号:US-6262260-B1
优先权日:2000-03-23
标 题:Process for the preparation of midazolam
发明人：DHAON MADHUP K
权利人:ABBOTT LAB
摘要:The present invention provides a process for the synthesis of compounds of formula (II) n or pharmaceutically acceptable salts thereof.
专利号:EP-1105392-B1
优先权日:1999-06-30
标 题:Process for the preparation of imidazodiazepine intermediates
发明人：DHAON MADHUP K; LABIB PARVIS; DAVIS DEBORAH A; ESSER GRANT L
权利人:ABBOTT LAB
摘要:The present invention relates to a process for the synthesis of a compound having formula XI, from a compound of formula X.
专利号:US-2011275799-A1
优先权日:2010-05-04
标题:PROCESS FOR THE SYNTHESIS OF 4H-IMIDAZO [1,5-a] [1,4] BENZODIAZEPINES, IN PARTICULAR MIDAZOLAM AND SALTS THEREOF
专利号:EP-2397470-B1
优先权日:2010-05-04
标题:Process for the synthesis of 4H-imidazo[1,5-a][1,4]benzodiazepines, in particular midazolam and salts thereof
