CAS: 59347-91-0; (S)-2-Phenylpyrrolidine

上下游产品

2-苯基吡咯烷 2-(Phenyl)Pyrrolidine 1006-64-0
5-Phenylpyrrolidin-2-One 56553-09-4
S-2-(2-溴苯基)四氢吡咯 (S)-2-(2-Bromophenyl)Pyrrolidine 1217680-27-7

5-苯基-3,4-二氢-2H-吡咯置于d-葡萄糖,Bacillus Subtilis Glucose Dehydrogenase 101,Imine Reductase-44,还原型辅酶ii(Nadph)四钠盐体系中,用 Aq. Phosphate Buffer,N,N-二甲基甲酰胺,甘油 作为反应溶剂,以67%的收率获得产物(S)-2-苯基吡咯烷
参考文献:非常规溶剂中亚胺还原酶对环状亚胺的不对称还原
标题:非常规溶剂中亚胺还原酶对环状亚胺的不对称还原
摘要:据报道,首次在非常规溶剂中通过亚胺还原酶 (Ired) 将 2-取代环状亚胺对映选择性还原为相应的手性胺(具有很高的药用价值).该过程可以在 100 Mm 底物负载下进行,并采用分批补料方法,并正式回收催化系统.这些特征带来了在经济和环境可持续性方面大规模应用的潜在兴趣.
DOI:10.1002/cssc.202301243

专利信息

专利号:US-9724682-B2
优先权日:2013-02-26
标 题 :Synthesis of acyclic and cyclic amines using iron-catalyzed nitrene group transfer
发明人：BETLEY THEODORE ALEXANDER; HENNESSY ELISABETH THERESE
权利人:HARVARD COLLEGE
摘要:The present invention provides novel synthetic methods for making acyclic secondary amines by reacting an azide with a compound bearing one or more C—H groups, catalyzed by a Fe II -dipyrromethene complex. The acyclic secondary amines are thought to be formed through an intermolecular nitrene transfer. Also provided herein are methods of synthesizing protected (e.g., Boc- or Fmoc-protected) cyclic secondary amines (e.g., 5-, 6-, and 7-membered cyclic secondary amines) by reacting an azide that bears one or more C—H groups, catalyzed by a Fe II -dipyrromethene complex. The protected cyclic secondary amines are thought to be formed through an intramolecular nitrene transfer and may be subsequently deprotected to yield cyclic secondary amines.

专利号:US-2017072390-A1
优先权日:2013-02-26
标 题 :Synthesis of acyclic and cyclic amines using iron-catalyzed nitrene group transfer

专利号:US-9695191-B2
优先权日:2009-08-05
标题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN
权利人:OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN; POLYPHOR AG
摘要:Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of type (I) are constituted by three distinct building blocks: an aromatic template a, a conformation modulator b and a spacer moiety c as detailed in the description and the claims. Macrocycles of type (I) are readily manufactured by parallel synthesis or combinatorial chemistry. They are designed to interact with specific biological targets. In particular, they show agonistic or antagonistic activity on the motilin receptor (MR receptor), on the serotonin receptor of subtype 5-HT 2B (5-HT 2B receptor), and on the prostaglandin F2•receptor (FP receptor). They are thus potentially useful for the treatment of hypomotility disorders of the gastrointestinal tract such as diabetic gastroparesis and constipation type irritable bowl syndrome; of CNS related diseases like migraine, schizophrenia, psychosis or depression; of ocular hypertension such as associated with glaucoma and preterm labour.