CAS: 57292-45-2; Boc-D-Phe(4-F)-Oh

上下游产品

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile L-4-fluorophenylalanine tert-butyl dicarbonatedi-tert-butyl dicarbonate 4-Fluorophenylalaninetert-butyl N-[(1S)-1-[(4-fluorophenyl)methyl]-2-[methoxy(methyl)amino]-2-oxo-ethyl]carbamate (S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-fluoro-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid; hydr°Chloride (S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-(4-fluoro-phenyl)-propionylamino]-4-methyl-pentanoic acid; hydr°Chloride B°C-Phe(4-F)-NMeBzl

📜Methyl (R)-2-Tert-Butoxycarbonylamino-3-(4-Fluorophenyl)Propanoate置于水,Lithium Hydroxide体系中,用 四氢呋喃,甲醇 作为反应溶剂,化学反应 6.0H,反应生成 Boc-D-4-氟苯丙氨酸
参考文献:Discovery Of Pyrrolopyrimidine Inhibitors Of Akt
标题:Discovery Of Pyrrolopyrimidine Inhibitors Of Akt
摘要:The Discovery And Optimization Of A Series Of Pyrrolopyrimidine Based Protein Kinase B (Pkb/akt) Inhibitors Discovered Via Hts And Structure Based Drug Design Is Reported. The Compounds Demonstrate Potent Inhibition Of All Three Akt Isoforms And Knockdown Of Phospho-Pras40 Levels In Lncap Cells And Tumor Xenografts. (C) 2010 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2010.08.053

专利信息

专利号:US-6514997-B2
优先权日:1999-12-03
标题:Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
发明人：DRAGOVICH PETER S; PRINS THOMAS J; ZHOU RU; JOHNNSON JR THEODORE O
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the picornaviral 3C protease. Also disclosed are compounds of the formula: n where the formula variables are as defined herein that advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.