CAS: 50889-29-7; (5-Carboxypentyl)Triphenylphosphonium Bromide

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CAS号404-86-4 辣椒碱 | CAS号40228-90-8 7-苯基庚酸 | CAS号946-33-8 2-苯甲基环己酮 | CAS号929-77-1 山嵛酸甲酯 | CAS号58-85-5 D-生物素 | CAS号26420-23-5 7-(3-THIENYL)HE... | CAS号59320-77-3 8-甲基壬-6-烯酸 | CAS号31467-60-4 (6Z)-8-甲基-6-壬烯酸 | CAS号95636-02-5 反-8-甲基-6-壬酰氯 | CAS号661-19-8 正二十二醇

6-溴己酸置于三苯基膦体系中,用 甲苯 作为反应溶剂,化学反应 17.0H,以100%的收率获得产物(5-羧基戊基)三苯基溴化磷
参考文献:细胞色素p450 Cyp505X对辣椒素的脂肪羟基化和环氧化作用
标题:细胞色素p450 Cyp505X对辣椒素的脂肪羟基化和环氧化作用
摘要:微生物细胞色素p450酶(cyp)能够模拟人cyp的代谢.一项挑战是鉴定相应的药物代谢物,并将底物特异性与人类酶的底物特异性进行比较.在这项研究中,来自烟曲霉的viii类自足cyp (cyp505X)及其酶的变体在大肠杆菌中异源表达.使用活性药物成分(api)和(杂环)化合物确定变体的底物范围.辣椒素(辣椒中的活性化合物)在全细胞介导的生物转化中被最有效地氧化(4.36μm/ Min).分离,纯化产物,并通过1D和2D NMR阐明其结构.这两种主要代谢物在亲脂性侧链上显示出修饰.具体地,将辣椒素在8位羟基化以得到(e)-8-羟基-N-(4-羟基-3-甲氧基苄基)-8-甲基非-6-烯酰胺并在双键上环氧化以得到n-(4-羟基-3-甲氧基苄基)-5-(3-异丙基环氧乙烷-2-基)-戊酰胺.
DOI:10.1016/j.Tet.2018.08.049

专利信息

专利号:US-4760068-A
优先权日:1982-06-14
标题:Certain pyridyl alkenoic acid derivatives which inhibit the action of thromboxane A2 synthetase
发明人：TERAO SHINJI; NISHIKAWA KOHEI
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:Novel compound of the formula: ##STR1## wherein R 1 is pyridyl group, R 2 is a phenyl group, a thienyl group, a furyl group, a naphthyl group, a benzothienyl group or pyridyl group, which may optionally have a lower alkoxy group, a lower alkyl group, a halogen atom, trifluoromethyl group, a lower alkenyl group or methylenedioxy group, R 3 is hydrogen atom or a lower alkyl group, and n is an integer of 0 to 6, Y is sulphur atom, methylene group or a group of the formula: ##STR2## wherein R 4 is hydrogen atom or acetyl group, and m is 0 or 1, and their pharmaceutically acceptable salts having an inhibitory action on bio-synthesis of thromboxane A 2 (TXA 2 ) and an effect of accelerating the productivility of prostaglandin I 2 (PGI 2 ), and can be used for mammals to the prophylaxis or therapy of thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardiac infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).

专利号:WO-2023137518-A1
优先权日:2022-01-21
标题 :Platinum complexes
发明人：ALDRICH-WRIGHT JANICE; GORDON CHRISTOPHER; DEO KRISHANT M; KHOURY ALEEN; MCGHIE BRONDWYN; APUTEN ANGELICO; PLATTEN-MENTI MARIA; RASHID FATIN; JURISINEC ASHLEY; SOLIMAN SARAH
权利人:WESTERN SYDNEY UNIV
摘要:The present disclosure relates to platinum complexes, and in particular platinum(II) and platinum(IV) complexes. The present disclosure also relates to synthesis of the platinum complexes, and to intermediates for the synthesis of the platinum complexes. The present disclosure also relates to methods and use of the platinum complexes for treating cancer.

专利号:US-6531614-B2
优先权日:1993-12-15
标题 :Method of prostaglandin synthesis
发明人：CONROW RAYMOND E
权利人:ALCON MFG LTD
摘要:Methods of synthesizing 9-Halo-13,14-dihydroprostaglandins useful in the treatment of glaucoma and ocular hypertension are disclosed. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.

专利号:US-4536505-A
优先权日:1983-05-17
标 题:Certain N-(pyridyl) indoles
发明人：BROWNE LESLIE J
权利人:CIBA GEIGY CORP
摘要:Disclosed are compounds of formula I ##STR1## wherein Ar is 3- or 4-pyridyl or 3- or 4-pyridyl substituted by lower alkyl; n R 1 is hydrogen, halogen, trifluoromethyl, lower alkyl, hydroxy, acylated or etherified hydroxy, lower alkyl-(thio, sulfinyl or sulfonyl), or two of R 1 on adjacent carbon atoms represent alkylenedioxy; n p is 1 or 2; n R 2 represents hydrogen or lower alkyl; one of R 3 and R 4 represents hydrogen and the other of R 3 and R 4 represents the group A-B in which n A represents alkylene of 1 to 12 carbon atoms, alkynylene or alkenylene of 2 to 12 carbon atoms each, lower alkylene-phenylene, lower alkylene-(thio or oxy)-lower alkylene, lower alkylene-(thio or oxy)-phenylene, lower alkylenephenylene-lower (alkylene or alkenylene), or alkadienylene or 4 to 12 carbon atoms; and n B represents carboxy, esterified carboxy, carbamoyl, mono- or di-lower alkylcarbamoyl, cyano, hydroxycarbamoyl, or 5-tetrazolyl; the pyridyl-N-oxides thereof; and pharmaceutically acceptable salts thereof; methods for their synthesis and pharmaceutical compositions thereof. These compounds are useful as selective thromboxane synthetase inhibitors for the treatment of diseases such as cerebral ischaemia, shock, thrombosis and ischaemic heart disease.

专利号:US-6344581-B1
优先权日:1993-12-15
标题 :Method of prostaglandin synthesis

专利号:US-2002107414-A1
优先权日:1993-12-15
标 题:Method of prostaglandin synthesis