CAS: 498-96-4; 1,2,5,6-Tetrahydropyridine-3-Carboxylic Acid

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CAS号5435-00-7 3-Piperidinecar... | CAS号17210-51-4 Guvacoline Hydr... | CAS号3518-88-5 3,3'-亚氨基二丙酸二乙酯 | CAS号101599-56-8 3,3'-benzoylimi... | CAS号495-19-2 1,2,5,6-四氢吡啶-3-羧酸甲酯 | CAS号300-08-3 氢溴酸槟榔碱 | CAS号121661-86-7 (N-chlor°Carbon... | CAS号59-67-6 烟酸 | CAS号614-18-6 烟酸乙酯 | CAS号498-95-3 3-哌啶甲酸 | CAS号108-99-6 3-甲基吡啶

氢溴酸槟榔碱置于水,Potassium Carbonate体系中,用 水 作为反应溶剂,化学反应 3.5H,反应生成 1,2,5,6-四氢吡啶-3-羧酸盐酸盐
参考文献:铱催化不饱和杂环酸的对映选择性加氢
标题:铱催化不饱和杂环酸的对映选择性加氢
摘要:螺旋结合:一种高度对映选择性的不饱和杂环羧酸的加氢已经通过使用手性铱/ Spirophosphino恶唑啉催化剂开发(参见方案; Bar ˚f-=四[3,5-双(三氟甲基)苯基]硼酸盐,的boc =叔丁氧羰基) .该反应提供了制备具有优异对映选择性的旋光杂环酸的有效方法.
DOI:10.1002/anie.201301341

专利信息

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:WO-2021072167-A1
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides