CAS: 412355-81-8; 4-Amino-1-(2-Pyrimidinyl)Piperidine

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CAS号180695-80-1 4-叠氮哌啶-1-羧酸叔丁酯

📜4-叠氮基哌啶-1-羧酸叔丁酯置于盐酸,10% Pt/activated Carbon,氢气,Potassium Carbonate体系中,用 四氢呋喃,1,4-二氧六环,二甲基亚砜 作为反应溶剂,化学反应 18.0H,反应生成 1-(2-嘧啶基)哌啶-4-胺
参考文献:Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design And High-Throughput Batch And Flow Technologies
标题:Disubstituted 1-Aryl-4-Aminopiperidine Library Synthesis Using Computational Drug Design And High-Throughput Batch And Flow Technologies
摘要:A Platform That Incorporates Computational Library Design,Parallel Solution-Phase Synthesis,Continuous Flow Hydrogenation,And Automated High Throughput Purification And Reformatting Technologies Was Applied To The Production Of A 120-Member Library Of 1-Aryl-4-Amino-Piperidine Analogues For Drug Discovery Screening. The Application Described Herein Demonstrates The Advantages Of Computational Library Design Coupled With A Flexible,Modular Approach To Library Synthesis. The Enabling Technologies Described Can Be Readily Adopted By The Traditional Medicinal Chemist Without Extensive Training And Lengthy Process Development Times.
DOI:10.1021/co400078R