CAS: 37107-81-6; 5-Vinylpyrimidine-2,4(1H,3H)-Dione

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65-71-4 65-71-4 4425-56-3

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CAS号77530-00-8 5-(2-bromoethyn... | CAS号7486-35-3 三丁基乙烯基锡 | CAS号696-07-1 5-碘尿嘧啶 | CAS号108-05-4 乙酸乙烯酯 | CAS号69304-49-0 (E)-5-(2-溴乙烯基)-... | CAS号125056-98-6 5-ethenyl-1-(2-... | CAS号55520-62-2 (5-ethenyl-2-tr... | CAS号55520-67-7 5-vinyl-2'-deox... | CAS号39541-85-0 5-(1-hydroxyeth...

📜5-(Bromoethynyl)-Uracil置于喹啉,Lindlar'S Catalyst,氢气体系中,用 甲醇 作为反应溶剂,化学反应 60.0H,以85%的收率获得产物5-乙烯尿嘧啶
参考文献:(z)-5-(2-溴乙烯基)-2'-脱氧尿苷的合成及抗病毒性能.
标题:(z)-5-(2-溴乙烯基)-2'-脱氧尿苷的合成及抗病毒性能.
摘要:通过电子异构体的光异构化获得(z)-5-(2-溴乙烯基)尿嘧啶.类似地,(e)-5-(2-溴乙烯基)-2'-脱氧尿苷给出了所需的z异构体.与z异构体相比,(z)-5-(2-溴乙烯基)-2'-脱氧尿苷对1型单纯疱疹病毒(hsv-1)的活性低得多,对2型单纯疱疹病毒的活性也低一些.两种异构体对牛痘病毒均显示出相似的活性.因此,(e)-5-(2-溴乙烯基)-2'-脱氧尿苷对hsv-1的高效和选择性活性是由于其e构型.
DOI:10.1021/jm00138A024

专利信息

专利号:US-5591852-A
优先权日:1990-08-10
标题 :Process for the preparation of nucleotides
发明人：VEMISHETTI PURUSHOTHAM; BRODFUEHRER PAUL R; HOWELL HENRY G; SAPINO JR CHESTER
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.

专利号:US-5214134-A
优先权日:1990-09-12
标题:Process of linking nucleosides with a siloxane bridge
发明人：WEIS ALEXANDER LUDVIK; SAHA ASHIS KUMAR; HAUSHEER FREDERICK HERMAN
权利人:STERLING WINTHROP INC
摘要:A method of linking nucleosides with a siloxane bridge comprising reacting a 3'-silylated-5'-protected nucleoside with an unprotected nucleoside is disclosed. The silylated and unprotected nucleosides may be either monomeric nucleosides or the terminal nucleosides of an oligonucleotide or oligonucleotide analog. A method of synthesizing an oligonucleotide analog having siloxane internucleoside linkages is also disclosed. The method of synthesis comprises silylating a 5'-protected nucleoside with a bifunctional silylating reagent to form a 3'-silylated nucleoside, reacting the silylated nucleoside with an unprotected nucleoside in the presence of a base catalyst and repeating these steps to form an oligonucleotide analog. A modified solid phase synthesis method for preparing an oligonucleotide analog having siloxane internucleoside linkages is also disclosed.

专利号:JP-2003513984-A
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-L-nucleoside

专利号:US-2011009606-A1
优先权日:2009-01-15
标题:Synthesis of 2',3' - and 3',5' -cyclic phosphate mono-and oligonucleotides

专利号:EP-1179598-B1
优先权日:1999-05-13
标题 :Process for producing nucleoside compound
发明人：NIKUMARU SEIYA; NAKAMURA TAKESHI
权利人:MITSUI CHEMICALS INC
摘要:In preparation of a nucleoside compound by reacting a pentose-1-phosphate and a nucleic acid base or its analogue in the presence of enzyme activity of nucleoside phosphorylase, a metal salt capable of forming a water-insoluble salt with phosphoric acid may be added to a reaction system to eliminate phosphoric acid, a byproduct, from the reaction system so that the equilibrium reaction can be shifted toward a direction for nucleoside synthesis, leading to an improved yield of the desired nucleoside compound.