专利号:WO-2025154001-A1 优先权日:2024-01-18 标 题:An improved process for the preparation of lumateperone and salt thereof 发明人:KANWAL PUSHKARNATH PANDITA; SURAPARAJU RAGHU RAM; C RAVEENDRA REDDY 权利人:OPTIMUS DRUGS PVT LTD 摘要:The present invention provides an improved process for the preparation of Lumateperone (I) and salts thereof with high yield and enhanced purity Furthermore, the present invention relates to the preparation of the compound of formula (VII), which is utilized in the synthesis of Lumateperone (I).
专利号:ES-2776889-T3 优先权日:2007-03-12 标题 :Synthesis of gamma-carbolines fused to substituted heterocycle
专利号:US-2023271983-A1 优先权日:2020-07-29 标题 :Functionalized isonitriles and products, preparation and uses thereof 发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA 权利人:UNIV SANTIAGO COMPOSTELA 摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.
专利号:US-11453670-B2 优先权日:2018-06-11 标 题:Substituted heterocycle fused gamma-carbolines synthesis 发明人:LI PENG; ZHANG QIANG 权利人:INTRA CELLULAR THERAPIES INC 摘要:The present invention provides improved methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines.
专利号:JP-6231151-B2 优先权日:2007-03-12 标题:Synthesis of substituted heterocyclic fused gamma-carbolines
专利号:JP-2010521464-A 优先权日:2007-03-12 标 题:Synthesis of substituted heterocyclic fused gamma-carbolines
1: Kumar B, Kuhad A, Kuhad A. Lumateperone: a new treatment approach for neuropsychiatric disorders. Drugs Today (Barc). 2018 Dec;54(12):713-719. doi: 10.1358/dot.2018.54.12.2899443.
合成参考文献
摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2026).