CAS: 2113-57-7; 3-Bromo-1,1'-Biphenyl

上下游产品

CAS号89598-96-9 3-溴苯硼酸 | CAS号71-43-2 苯 | CAS号108-36-1 1,3-二溴苯 | CAS号98-80-6 苯硼酸 | CAS号66107-31-1 3-bromophenyl t... | CAS号38111-44-3 苯基溴化锌 | CAS号591-18-4 1-溴-3-碘苯 | CAS号591-20-8 3-溴苯酚 | CAS号5455-13-0 5-溴-[1,1'-联苯]-2-胺 | CAS号27246-81-7 3-溴苯肼盐酸盐 | CAS号5122-95-2 3-联苯硼酸 | CAS号42498-44-2 联苯-3-甲酰氯 | CAS号23948-77-8 2-([1,1'-联苯]-3-基)乙酸 | CAS号716-76-7 3-苯基苯甲酸 | CAS号65685-01-0 联苯-3-磺酰氯 | CAS号3378-09-4 二苯-3-基(苯)甲酮 | CAS号1204-60-0 联苯基-3-甲醛 | CAS号24973-50-0 [1, 1'-联苯]-3-甲腈 | CAS号198275-79-5 N-苯基-3-联苯胺 | CAS号121168-49-8 (2-aminophenyl)...

间溴苯酚置于[1,3-双(二苯基膦基)丙烷]二氯化钯(II) 吡啶体系中,用 四氢呋喃 用作溶剂,化学反应 11.0H,反应生成3-溴联苯
参考文献:Aryl Bromide/triflate Selectivities Reveal Mechanistic Divergence In Palladium-Catalysed Couplings; The Suzuki-miyaura Anomaly
标题:Aryl Bromide/triflate Selectivities Reveal Mechanistic Divergence In Palladium-Catalysed Couplings; The Suzuki-miyaura Anomaly
摘要:在催化交叉反应中,和三之间的竞争的结果取决于核性伴侣;苏苏基与r.b的交叉通常跟随其他r.m物种的不同模式.
Doi:10.1039/b701517H

专利信息

专利号:US-5254776-A
优先权日:1992-07-17
标 题:Synthesis of bromobiphenyls
发明人：LANG JOHN F; GURUSAMY NARAYANASAMY
权利人:MALLINCKRODT SPEC CHEM
摘要:Bromobiphenyls (such as 2-fluoro-4-bromobiphenyl) are synthesized by reacting together a phenylboronic acid (such as phenylboronic acid) and a bromoiodobenzene (such as 2-fluoro-4-bromoiodobenzene). The reaction generally takes place with the aid of a catalyst (such as palladium in a zero valance state) and an inert solvent (such as fluorobenzene). Control of temperature is very important to obtain both an acceptable reaction rate and an acceptable level of terphenyl byproduct.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6849650-B2
优先权日:1998-02-27
标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-11028082-B2
优先权日:2017-05-30
标题 :Process for the preparation of a novel umeclidinium synthesis intermediate
发明人：BERTOLINI GIORGIO; COLLI CORRADO; NISIC FILIPPO; SADA MARA; BERTUOLO STEFANIA; RONZONI SILVANO; MAIORANA STEFANO; DI FABIO ROMANO
权利人:OLON SPA
摘要:The present invention relates to a process for the preparation of a novel and versatile synthesis intermediate and its use in the preparation of umeclidinium. The invention also relates to some reference standards allowing to detect impurity traces recurring in the preparation of umeclidinium and a process for their preparation.