CAS: 207446-90-0; (3R,3As,6R,6As,9R,10R,10As)-9,10-Dihydroxy-3,6,9-Trimethyldecahydro-2H-Naphtho[8A,1-B]Furan-2-One

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(3R,3a,6R,6aS,10aS)-3a,4,5,6,6a,7,8,8a-°Ctahydro-3,6,9-trimethylnaphtho[8a,1-b]furan-2(3H)-one

📜Dihydro-Epi-Deoxyarteannuin B置于四氧化锇,Potassium Carbonate,Potassium Hexacyanoferrate(III)体系中,用 水,叔丁醇 用作溶剂,以58%的收率获得青蒿素 M
参考文献:Structure Elucidation Of Arteannuin O,A Novel Cadinane Diol From Artemisia Annua,And The Synthesis Of Arteannuins K,L,M And O
标题:Structure Elucidation Of Arteannuin O,A Novel Cadinane Diol From Artemisia Annua,And The Synthesis Of Arteannuins K,L,M And O
摘要:The Novel Cadinane Diol,Arteannuin O (1),Has Been Obtained From Artemisia Annua And Its Structure Has Been Established By 2D NMR And X-Ray Crystallography. A Reconstructive Synthesis Of Arteannuin O From Artemisinin Is Described,Which Also Yields The Natural Products Arteannuin K And Arteannuin L. Mechanistic Considerations Have Led To The Conclusion That The Stereochemistry Of The 5-Hydroxyl Group Was Wrongly Assigned When Arteannuins K,L And M Were First Reported As Natural Products. This Was Confirmed By Derivatization Of Synthetic Arteannuins K,L And M As Their Mosher Esters. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0040-4020(01)00633-0