专利号:US-8110642-B2 优先权日:2006-05-08 标 题:Synthesis of vinylphenylpyridine and living anionic polymerization 发明人:LEE JAE-SUK; KANG NAM-GOO 权利人:LEE JAE-SUK; KANG NAM-GOO; KWANGJU INST SCI & TECH 摘要:Provided are a vinyl-biphenylpyridine monomer and a polymer thereof. More particularly, the present invention provides a vinyl-biphenylpyridine monomer having a side chain of pyridine or phenylpyridine as a functional group, a homopolymer of which molecular weight and molecular weight distribution are controlled using the monomer, and a block copolymer of which molecular structure and molecular weight are controlled to facilitate synthesis of an organic metal complex. Accordingly, the present invention provides a vinyl-biphenylpyridine monomer and a polymer thereof which are effectively used as nano and optical functional materials.
专利号:US-9695169-B2 优先权日:2012-05-31 标 题:Synthesis of heterocyclic compounds 发明人:IBRAHIM PRABHA N 权利人:PLEXXIKON INC 摘要:Provided herein are intermediates and processes useful for facile synthesis of biologically active molecules.
专利号:US-11008273-B2 优先权日:2019-02-15 标题 :Process for the manufacture of fluorinated benzenes and fluorinated benzophenones, and derivatives thereof 发明人:ZHOU CHANGYUE; DU HONGJUN; WU WENTING 权利人:FUJIAN YONGJING TECH CO LTD 摘要:The invention relates to a new process for the manufacture or synthesis, respectively, of fluorinated benzenes and fluorinated benzophenones, and derivatives thereof, in particular of fluorobenzenes and derivatives thereof. The present invention particularly pertains to a novel environmentally friendly process for the synthesis of fluorinated benzenes and benzophenones as raw materials for the manufacture of polyaryletherketones (PAEKs).
专利号:EP-4421075-A1 优先权日:2023-02-27 标 题 :Process for the preparation of venetoclax and intermediates used therein 发明人:BERGANT SIMONCIC ANA 权利人:KRKA D D NOVO MESTO 摘要:The invention relates to a process for the synthesis of Venetoclax. The invention further relates to intermediates that are useful in the synthesis of Venetoclax.
专利号:US-8710261-B2 优先权日:2005-02-22 标 题:5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases 发明人:PALLE VENKATA P; SATTIGERI VISWAJANANI JITENDRA; KHERA MANOJ KUMAR; VOLETI SREEDHARA RAO; RAY ABHIJIT; DASTIDAR SUNANDA G 权利人:PALLE VENKATA P; SATTIGERI VISWAJANANI JITENDRA; KHERA MANOJ KUMAR; VOLETI SREEDHARA RAO; RAY ABHIJIT; DASTIDAR SUNANDA G; RANBAXY LAB LTD 摘要:The present invention relates to Compounds having the structure of Formula I: wherein n is an integer from 1 to 5; R 1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R 2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR 4 R 5 , —NHC(â•?Y)R 4 , —NHC(â•?Y)NR 5 R χ , —NHC(â•?O)OR 4 , —NHSO 2 R 4 , C(â•?Y)NR 4 R 5 , C(â•?O)OR 6 [wherein Y is oxygen or sulphur], OR 5 , —O(Câ•?O)NR 4 R 5 , O-acyl, S(O) m R 4 , —SO 2 N(R 4 ) 2 , cyano, amidino or guanidino [wherein R 4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R 5 is hydrogen or R 4 ; R x is R 4 or —SO 2 N(R 4 ) 2 and R 6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R 3 is hydrogen, fluorine, alkyl, cycloalkylalkyl or aralkyl; A is OH, OR 4 , —OC(â•?O)NR 4 R 5 , O-acyl, NH 2 , NR 4 R 5 , —NHC(â•?Y)R 4 , —NHC(â•?Y)NR 5 R x , —NHC(â•?O)OR 4 , —NHSO 2 R 4 , and to processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterize by over-expression and over-activation of an matrix metalloproteinase, using the compounds.
专利号:US-12319691-B2 优先权日:2020-05-04 标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use 发明人:CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI 权利人:AMGEN INC; VIGIL NEUROSCIENCE INC 摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.
[参考文献]: Kiyofumi Inamoto, Et Al. Tandem-Type Pd(Ii)-Catalyzed Oxidative Heck Reaction/intramolecular C-H Amidation Sequence: A Novel Route To 4-Aryl-2-Quinolinones. Chem Commun (Camb). 2012 May 7;48(36):4332-4. [参考文献]: Kun Shen, Et Al. Cationic Pd(Ii)-Catalyzed Highly Enantioselective Arylative Cyclization Of Alkyne-Tethered Enals Or Enones Initiated By Carbopalladation Of Alkynes With Arylboronic Acids. Org Lett. 2012 Apr 6;14(7):1756-9. [参考文献]: Navid Dastbaravardeh, Et Al. Ruthenium(0)-Catalyzed Sp3 C-H Bond Arylation Of Benzylic Amines Using Arylboronates. Org Lett. 2012 Apr 6;14(7):1930-3.
合成参考文献
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