CAS: 161671-34-7; Tert-Butyl (R)-3-Amino-3-Phenylpropanoate
该化合物是一种在制药合成和不对称催化中广泛使用的手性中间体,其异丁基酯组群增强了稳定性和溶解性,便于有机反应的处理.(R)-亚丁基酯纯度使得它对于产生光活化合物,特别是在合成β-氨基酸和聚胺胺基中具有价值.苯丙基丙酸脊椎为进一步功能化提供了多功能的支架.该化合物通常用于药用化学,用于开发生物活性分子,因为其具有明确的立体化学特性,并且与各种组合反应相容.高纯度等级确保研究和工业应用的再生.
- 英文名称Tert-Butyl (R)-3-Amino-3-Phenylpropanoate
- 中文名称(R)-3-氨基-3-苯基丙酸叔丁酯
- IUPAC名称tert-butyl (R)-3-amino-3-phenylpropanoate
- 其它别名(3R)-3-氨基-3-苯基丙酸叔丁酯; Tert-Butyl (3R)-3-Amino-3-Phenylpropanoate
- CAS编号161671-34-7
- MFCD编号:MFCD00798309
- 分子式:C13H19NO2分子量:221.3
- 产品CID: 816492
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
614-19-7 13921-90-9 40856-44-8物理性质
MSDS等安全信息
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📜1-Tert-Butoxy-1-(Trimethylsiloxy)Ethylene置于palladium On Activated Charcoal (R)-Binaphthol,硼酸三甲酯,4 A Molecular Sieve,氢气体系中,用 甲醇 用作溶剂,-78.0~25.0 °C,101.33 Kpa 条件下,反应 34.17H,反应生成(3R)-3-氨基-3-苯基丙酸叔丁酯
参考文献:A New Chiral Bla Promoter For Asymmetric Aza Diels-Alder And Aldol-Type Reactions Of Imines
标题:A New Chiral Bla Promoter For Asymmetric Aza Diels-Alder And Aldol-Type Reactions Of Imines
摘要:A New Type Of Chiral Promoter For Double Asymmetric Inductions Of Aza Diels-Alder And Aldol-Type Reactions Of Imines Is Prepared From Trialkyl Berates (B(Ome)(3) Or B(Oph)(3)) And Optically Pure Binaphthol; X-Ray Analysis Of The Boron Complex Demonstrates That It Exists As A Bronsted Acid-Assisted Chiral Lewis Acid(Bla). The Aldol-Type Reactions Of A Number Of N-Benzhydrylimines Derived From Aromatic Aldehydes With The Ketene Silyl Acetal Derived From Tert-Butyl Acetate Mediated By The Chiral Bla Afford Beta-Amino Acid Esters With High Enantioselectivity. The Solution Conformations Of The Bla.Imine Complexes Have Been Studied Using H-1 NMR Analysis And Difference Noe Measurements. The Absolute Configurations Of The Adducts Can Be Understood In Terms Of A Rational Model Involving An Intramolecular Hydrogen Binding Interaction Via A Bronsted Acid.
Doi:10.1021/ja00102A019
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2909110000-乙醚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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主要参考文献
参考标题:Total Synthesis Of Novel Antibiotics Pyloricidin A, B And C And Their Application In The Study Of Pyloricidin Derivatives.作者:Atsushi Hasuoka,Yuji Nishikimi,Yutaka Nakayama,Keiji Kamiyama,Masafumi Nakao,Ken-Ichiro Miyagawa,Osamu Nishimura,Masahiko Fujino
摘要:The Novel Natural Antibiotics Pyloricidin A, B And C, Which Possess Potent And Highly Selective Anti-Helicobacter Pylori Activity, Were Synthesized From D-Galactosamine As A Chiral Template For The Common (2S, 3R, 4R, 5S)-5-Amino-2, 3, 4, 6-Tetrahydroxyhexanoic Acid Moiety. The Synthetic Strategy, Using 2-Amino-2-Deoxyuronic Acid Derivatives As Key Intermediates, Was Also Useful To Prepare A Series Of Derivatives Modified At The β-D-Phenylalanine And With Altered Stereochemistry On The 5-Amino-2, 3, 4, 6-Tetrahydroxyhexanoic Acid Moiety. From The Drastic Decrease Of Their Anti-H. Pylori Activity, It Was Clear That The β-D-Phenylalanine Part And The Stereochemistry Of The 5-Amino-2, 3, 4, 6-Tetrahydroxyhexanoic Acid Moiety Were Significant For The Activity.
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